Recombinant Anti-LGR4 Vesicular Antibody, EV Displayed (VS-0425-YC354)
CAT#: VS-0425-YC354
The Recombinant Anti-LGR4 Vesicular Antibody, EV Displayed (VS-0425-YC354) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LGR4-expressed cells or tissues. The LGR4 is a GPCR that binds R-spondins to activate the Wnt pathway, essential for organ development.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to centriolar satellites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54350/869_B12_4_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human breast
Immunohistochemical staining of human breast shows strong positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_B_9_5.jpg
Normal Tissue
Figure 4 Adrenal gland
Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_B_6_5.jpg
Normal Tissue
Figure 5 Colon
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_9_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_4_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HAP1, RPTEC TERT1, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000205213-LGR4
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LGR4
- Host Animal
- Rat
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Leucine rich repeat containing G protein-coupled receptor 4
- Biological Process
- Biological rhythms, Differentiation, Immunity, Innate immunity, Spermatogenesis, Wnt signaling pathway
- Molecular Function
- Developmental protein, G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Centrosome, Centriolar satellite, Basal body
- Introduction
- The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body.
- Alternative Names
- GPR48
- Gene ID
- 55366
- UniProt ID
- Q9BXB1
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Datasheet
MSDS
COA
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See other products for "LGR4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0202CL | Rat Anti-LGR4 Recombinant Antibody (TAB-0202CL) | ELISA, In vivo | Rat IgG |
| TAB-0203CL | Rat Anti-LGR4 Recombinant Antibody (TAB-0203CL) | ELISA, IP, Inhib, In vivo | Rat IgG |
| TAB-0202CL-S(P) | Rat Anti-LGR4 Recombinant Antibody; scFv Fragment (TAB-0202CL-S(P)) | ELISA, In vivo | Rat scFv |
| TAB-0203CL-S(P) | Rat Anti-LGR4 Recombinant Antibody; scFv Fragment (TAB-0203CL-S(P)) | ELISA, IP, Inhib, In vivo | Rat scFv |
| TAB-0202CL-F(E) | Rat Anti-LGR4 Recombinant Antibody; Fab Fragment (TAB-0202CL-F(E)) | ELISA, In vivo | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0213-WJ | Rat Anti-LGR4 Recombinant Antibody (HPAB-0213-WJ) | WB | Rat IgG |
| HPAB-0214-WJ | Rat Anti-LGR4 Recombinant Antibody (HPAB-0214-WJ) | WB | Rat IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0213-WJ-S(P) | Rat Anti-LGR4 Recombinant Antibody; scFv Fragment (HPAB-0213-WJ-S(P)) | WB | Rat scFv |
| HPAB-0214-WJ-S(P) | Rat Anti-LGR4 Recombinant Antibody; scFv Fragment (HPAB-0214-WJ-S(P)) | WB | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0213-WJ-F(E) | Rat Anti-LGR4 Recombinant Antibody; Fab Fragment (HPAB-0213-WJ-F(E)) | WB | Rat Fab |
| HPAB-0214-WJ-F(E) | Rat Anti-LGR4 Recombinant Antibody; Fab Fragment (HPAB-0214-WJ-F(E)) | WB | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY172 | AbPlus™ Anti-LGR4 Magnetic Beads (VS-0424-XY172) | IP, Protein Purification |
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