Recombinant Anti-LGR4 Vesicular Antibody, EV Displayed (VS-0425-YC354) (CAT#: VS-0425-YC354)
The Recombinant Anti-LGR4 Vesicular Antibody, EV Displayed (VS-0425-YC354) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LGR4-expressed cells or tissues. The LGR4 is a GPCR that binds R-spondins to activate the Wnt pathway, essential for organ development.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54350/869_B12_4_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54350/869_B12_4_selected.jpg
Figure 2 IHC staining of human breast
(Immunohistochemical staining of human breast shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/ihc_selected.jpg
(Immunohistochemical staining of human breast shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_B_9_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_B_9_5.jpg
Figure 4 Adrenal gland
(Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_B_6_5.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_B_6_5.jpg
Figure 5 Colon
(Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_9_3.jpg
(Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_9_3.jpg
Figure 6 Kidney
(Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_8_5.jpg
(Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_8_5.jpg
Figure 7 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_4_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_4_6.jpg
Figure 8 Lymph node
(Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_9_8.jpg
(Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30267/65916_A_9_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (HAP1, RPTEC TERT1, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000205213-LGR4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000205213-LGR4
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LGR4
- Host Animal
- Rat
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Leucine rich repeat containing G protein-coupled receptor 4
- Biological Process
- Biological rhythms, Differentiation, Immunity, Innate immunity, Spermatogenesis, Wnt signaling pathway
- Molecular Function
- Developmental protein, G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Centrosome, Centriolar satellite, Basal body
- Introduction
- The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body.
- Alternative Names
- GPR48
- Gene ID
- 55366
- UniProt ID
- Q9BXB1
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0202CL | Rat Anti-LGR4 Recombinant Antibody (TAB-0202CL) | ELISA, In vivo | Rat IgG |
| TAB-0202CL-S(P) | Rat Anti-LGR4 Recombinant Antibody; scFv Fragment (TAB-0202CL-S(P)) | ELISA, In vivo | Rat scFv |
| TAB-0203CL-S(P) | Rat Anti-LGR4 Recombinant Antibody; scFv Fragment (TAB-0203CL-S(P)) | ELISA, IP, Inhib, In vivo | Rat scFv |
| TAB-0202CL-F(E) | Rat Anti-LGR4 Recombinant Antibody; Fab Fragment (TAB-0202CL-F(E)) | ELISA, In vivo | Rat Fab |
| TAB-0203CL-F(E) | Rat Anti-LGR4 Recombinant Antibody; Fab Fragment (TAB-0203CL-F(E)) | ELISA, IP, Inhib, In vivo | Rat Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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