Recombinant Anti-LRP6 Vesicular Antibody, EV Displayed (VS-0425-YC367)
CAT#: VS-0425-YC367
The Recombinant Anti-LRP6 Vesicular Antibody, EV Displayed (VS-0425-YC367) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LRP6-expressed cells or tissues. The LRP6 is involved in Wnt signaling pathways, influencing nervous system development and morphogenesis, with studies linking it to neural tube defects.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LRP6
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- LDL receptor related protein 6
- Biological Process
- Endocytosis, Wnt signaling pathway
- Molecular Function
- Developmental protein, Receptor
- Introduction
- Enables Wnt-protein binding activity; apolipoprotein binding activity; and toxin transmembrane transporter activity. Involved in cell surface receptor signaling pathway; positive regulation of neuron projection development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including central nervous system development; embryonic morphogenesis; and regionalization. Located in early endosome and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study neural tube defect and steatotic liver disease. Human ortholog(s) of this gene implicated in tooth agenesis.
- Alternative Names
- Cd; Gw; ska26; skax26; ska
; C030016K15Rik
- Gene ID
- 16974
- UniProt ID
- O88572
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Hepatocellular Carcinoma
Pancreatic Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0705CL | Human Anti-LRP6 Recombinant Antibody (TAB-0705CL) | ELISA, FC, Inhib | Human antibody |
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| TAB-0707CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0707CL-F(E)) | ELISA | Human Fab |
| TAB-0708CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0708CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
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| TAB-0092CL-F(E) | Mouse Anti-LRP6 Recombinant Antibody Fab Fragment (TAB-0092CL-F(E)) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0093CL-F(E) | Mouse Anti-LRP6 Recombinant Antibody Fab Fragment (TAB-0093CL-F(E)) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0094CL-F(E) | Mouse Anti-LRP6 Recombinant Antibody Fab Fragment (TAB-0094CL-F(E)) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0095CL-F(E) | Mouse Anti-LRP6 Recombinant Antibody Fab Fragment (TAB-0095CL-F(E)) | ELISA, FC, Inhib, FuncS, Internalization |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-0350CL-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (TAB-0350CL-S(P)) | ELISA | Humanized scFv |
| TAB-0351CL-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (TAB-0351CL-S(P)) | ELISA | Humanized scFv |
| TAB-0352CL-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (TAB-0352CL-S(P)) | ELISA | Humanized scFv |
| TAB-0353CL-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (TAB-0353CL-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0647-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0647-WJ) | ELISA | Human IgG |
| HPAB-0648-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0648-WJ) | ELISA | Human IgG |
| HPAB-0649-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0649-WJ) | ELISA | Human IgG |
| VS7-0425-WR317 | Mouse Anti-LRP6 Recombinant Antibody (clone 1A3F5) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-205 | Mouse Anti-LRP6 Recombinant Antibody Fab Fragment (PFBC-205) | ELISA, WB, FC | Mouse Fab |
| HPAB-0007-FY-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0007-FY-F(E)) | ELISA | Human Fab |
| HPAB-0012-FY-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0012-FY-F(E)) | FuncS, Cyt | Human Fab |
| HPAB-0647-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0647-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0648-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0648-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2087 | Hi-Affi™ Recombinant Rabbit Anti-LRP6 Monoclonal Antibody (DS2087AB) | ICC, IF, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0647-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0647-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0648-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0648-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0649-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0649-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0650-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0650-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0651-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0651-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0060-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (NBD-0060-YJ-VHH) | ELISA, Block | Camelid VHH |
| NBD-0061-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (NBD-0061-YJ-VHH) | ELISA, Block | Camelid VHH |
| NBD-0062-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (NBD-0062-YJ-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY82 | Human Anti-LRP6 scFv-Fc Chimera (VS-0325-FY82) | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4100 | Anti-LRP6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4101 | Anti-Human LRP6 Immunohistochemistry Kit | IHC |
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