Recombinant Anti-MCAM Vesicular Antibody, EV Displayed (VS-0425-YC149)
CAT#: VS-0425-YC149
The Recombinant Anti-MCAM Vesicular Antibody, EV Displayed (VS-0425-YC149) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MCAM-expressed cells or tissues. The MCAM is the Melanoma Cell Adhesion Molecule, related to melanoma and metastasis, involved in adhesion pathways.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2147/if_selected.jpg
Normal Tissue
Figure 2 Soft tissue
Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_B_2_7.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Low Intensity: Weak Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, TIME, WM-115)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000076706-MCAM
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MCAM
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Melanoma cell adhesion molecule
- Biological Process
- Cell adhesion
- Cellular Localization
- Plasma membrane
- Introduction
- MCAM (Melanoma Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with MCAM include Melanoma and Melanoma Metastasis. Among its related pathways are Adhesion. An important paralog of this gene is BCAM.
- Alternative Names
- CD146, HEMCAM, MelCAM, METCAM, MUC18
- Gene ID
- 4162
- UniProt ID
- P43121
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Datasheet
MSDS
COA
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See other products for "MCAM"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-516CL | Anti-Human MCAM Recombinant Antibody (ABX-MA1) | WB, FuncS | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-441MZ | Mouse Anti-MCAM Recombinant Antibody (TAB-441MZ) | FC, FuncS | Mouse IgG1 |
| TAB-441MZ-S(P) | Mouse Anti-MCAM Recombinant Antibody; scFv Fragment (TAB-441MZ-S(P)) | FC, WB, IHC | Mouse scFv |
| TAB-441MZ-F(E) | Mouse Anti-MCAM Recombinant Antibody; Fab Fragment (TAB-441MZ-F(E)) | FC, WB, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-442MZ | Human Anti-MCAM Recombinant Antibody (TAB-442MZ) | FC, WB, IHC | Chimeric (Mouse/Human) IgG1 |
| TAB-443MZ | Human Anti-MCAM Recombinant Antibody (TAB-443MZ) | FC, WB, IHC | Chimeric (Mouse/Human) IgG3 |
| TAB-442MZ-S(P) | Human Anti-MCAM Recombinant Antibody; scFv Fragment (TAB-442MZ-S(P)) | FC, WB, IHC | Human scFv |
| TAB-442MZ-F(E) | Human Anti-MCAM Recombinant Antibody; Fab Fragment (TAB-442MZ-F(E)) | FC, WB, IHC | Chimeric (Mouse/Human) Fab |
| TAB-443MZ-F(E) | Human Anti-MCAM Recombinant Antibody; Fab Fragment (TAB-443MZ-F(E)) | FC, WB, IHC | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-444MZ | Anti-Human MCAM Recombinant Antibody (TAB-444MZ) | ELISA | Humanized antibody |
| TAB-444MZ-S(P) | Anti-Human MCAM Recombinant Antibody scFv Fragment (TAB-444MZ-S(P)) | ELISA | Humanized antibody |
| TAB-444MZ-F(E) | Anti-Human MCAM Recombinant Antibody Fab Fragment (TAB-444MZ-F(E)) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0382CT | Recombinant Mouse anti-Human MCAM Monoclonal antibody (O2349) | IHC-P, WB | |
| HPAB-0493LY | Human Anti-MCAM Recombinant Antibody (clone H5L0) | ELISA | Humanized IgG1 |
| HPAB-0494LY | Human Anti-MCAM Recombinant Antibody (clone H10L2) | ELISA | Humanized IgG1 |
| HPAB-0495LY | Human Anti-MCAM Recombinant Antibody (clone H14L0) | ELISA | Humanized IgG1 |
| HPAB-0496LY | Human Anti-MCAM Recombinant Antibody (clone H11L3) | ELISA | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2188 | Hi-Affi™ Recombinant Rabbit Anti-MCAM Monoclonal Antibody (DS2188AB) | ICC, IF, IHC-Fr, WB, IP, IHC-P, ICC, FC | IgG |
| MOR-4644 | Hi-Affi™ Recombinant Rabbit Anti-MCAM Monoclonal Antibody (TH157DS) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0018-CN-S(P) | Mouse Anti-MCAM Recombinant Antibody (clone c264); scFv Fragment | FC | Mouse scFv |
| HPAB-0493LY-S(P) | Human Anti-MCAM Recombinant Antibody (clone H5L0); scfv Fragment | ELISA | Humanized scfv |
| HPAB-0494LY-S(P) | Human Anti-MCAM Recombinant Antibody (clone H10L2); scfv Fragment | ELISA | Humanized scfv |
| HPAB-0495LY-S(P) | Human Anti-MCAM Recombinant Antibody (clone H14L0); scfv Fragment | ELISA | Humanized scfv |
| HPAB-0496LY-S(P) | Human Anti-MCAM Recombinant Antibody (clone H11L3); scfv Fragment | ELISA | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0204-YJ-F(E) | Human Anti-MCAM Recombinant Antibody (clone Hu2120); Fab Fragment | FC, Neut, Block, IF, ELISA | Human Fab |
| HPAB-1127WJ-F(E) | Mouse Anti-MCAM Recombinant Antibody (clone C3.19.1); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1128WJ-F(E) | Mouse Anti-MCAM Recombinant Antibody (clone C6.11.3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1129WJ-F(E) | Mouse Anti-MCAM Recombinant Antibody (clone C3.10); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1176WJ-F(E) | Human Anti-MCAM Recombinant Antibody (clone c3.19.1); Fab Fragment | Inhib, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY185 | AbPlus™ Anti-MCAM Magnetic Beads (ScFv7) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY42 | Mouse Anti-MCAM (clone AA98) scFv-Fc Chimera | ELISA, FC, Inhib, IHC-Fr, WB, IP | Human IgG1, scFv-Fc |
| VS-0125-FY43 | Mouse Anti-MCAM (clone B6-11) scFv-Fc Chimera | WB, ELISA, IF | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4291 | Anti-MCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY4292 | Anti-Mouse MCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY4293 | Anti-Rat MCAM Immunohistochemistry Kit | IHC |
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