Recombinant Mouse Anti-MME Antibody (clone 2D12B3)
CAT#: VS3-FY228
This product is a recombinant mouse antibody that recognizes MME protein. This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry.
Gene Expression
Normal Tissue
Figure 1 Duodenum
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
Normal Tissue
Figure 2 High expression in small intestine
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
❮
❯
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- MME
- Clone
- 2D12B3
- Applications
- Enzyme-linked Immunosorbent Assay, Flow Cytometry
- Conjugate
- Unconjugated
Product Property
- Purity
- >95%
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry.
Target
- Alternative Names
- Membrane Metalloendopeptidase; Common Acute Lymphocytic Leukemia Antigen; Neutral Endopeptidase 24.11; Skin Fibroblast Elastase; Neutral Endopeptidase; Atriopeptidase; Enkephalinase; EC 3.4.24.11; Neprilysin; CALLA; NEP; SFE
- Gene ID
- 4311
- UniProt ID
- P08473
- Sequence Similarities
- Belongs to the peptidase M13 family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Myristoylation is a determinant of membrane targeting.
Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
- Protein Refseq
- NP_000893.2; NP_009218.2; NP_009219.2
- Function
- Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:6349683, PubMed:6208535, PubMed:15283675, PubMed:8168535).
Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991).
Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535).
Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:6349683, PubMed:15283675).
Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:2531377, PubMed:2972276, PubMed:16254193).
Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-FY228. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "MME"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1454z | Mouse Anti-MME Recombinant Antibody (clone 24C6) | WB, FC, IF, IHC | Mouse IgG1, κ |
| ZG-0075J | Mouse Anti-MME Recombinant Antibody (clone 5B8) | IF, ICC, IHC-P | Mouse IgG |
| ZG-0001U | Rabbit Anti-MME Recombinant Antibody (clone 10G11) | ELISA, IHC | Rabbit IgG |
| VS3-FY227 | Recombinant Mouse Anti-MME Antibody (clone 1H8C10) | ELISA, WB, FC, IHC | Mouse IgG2b |
| VS3-FY229 | Recombinant Mouse Anti-MME Antibody (clone 2D12D1) | ELISA, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L033R | anti-MME immunotoxin SN5d (Fab)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L034R | anti-MME immunotoxin SN5d (IgG)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2246 | Hi-Affi™ Recombinant Rabbit Anti-MME Monoclonal Antibody (DS2246AB) | ICC, IF, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244-FY-S(P) | Recombinant Human Anti-MME Antibody scFv Fragment | F | Human scFv |
| HPAB-0311-YJ-S(P) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); scFv Fragment | IHC, ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244-FY-F(E) | Recombinant Human Anti-MME Antibody Fab Fragment | F | Human Fab |
| HPAB-0311-YJ-F(E) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); Fab Fragment | IHC, ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY1083 | Mouse Anti-MME Recombinant Antibody (clone 307CT12.12.5) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC682 | AbPlus™ Anti-MME Magnetic Beads (VS-0724-YC682) | IP, Protein Purification | |
| VS-0724-YC779 | AbPlus™ Anti-MME Magnetic Beads (VS-0724-YC779) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC720 | Recombinant Anti-MME Vesicular Antibody, EV Displayed (VS-0425-YC720) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4431 | Anti-MME Immunohistochemistry Kit | IHC | |
| VS-0525-XY4432 | Anti-Mouse MME Immunohistochemistry Kit | IHC | |
| VS-0525-XY4433 | Anti-Rat MME Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: Block, Cyt, FuncS, Inhib
Application: ELISA, Neut, FuncS
Application: ELISA, SPR, Inhib, FuncS
-2.jpg)
Application: IB, ELISA, FC, FuncS
Application: WB, ELISA, IF
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, Inhib, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
