Recombinant Mouse Anti-MME Antibody (clone 5C11D6) (CAT#: VS3-FY230)
This product is a recombinant mouse antibody that recognizes MME protein. This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry.
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Normal Tissue
RNA Expression
Figure 1 Duodenum
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
Figure 2 High expression in small intestine
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
Figure 3 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- MME
- Clone
- 5C11D6
- Applications
- Enzyme-linked Immunosorbent Assay, Flow Cytometry
- Conjugate
- Unconjugated
Product Property
- Purity
- >95%
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry.
Target
- Alternative Names
- Membrane Metalloendopeptidase; Common Acute Lymphocytic Leukemia Antigen; Neutral Endopeptidase 24.11; Skin Fibroblast Elastase; Neutral Endopeptidase; Atriopeptidase; Enkephalinase; EC 3.4.24.11; Neprilysin; CALLA; NEP; SFE
- Gene ID
- 4311
- UniProt ID
- P08473
- Sequence Similarities
- Belongs to the peptidase M13 family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Myristoylation is a determinant of membrane targeting.
Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
- Protein Refseq
- NP_000893.2; NP_009218.2; NP_009219.2
- Function
- Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:6349683, PubMed:6208535, PubMed:15283675, PubMed:8168535).
Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991).
Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535).
Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:6349683, PubMed:15283675).
Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:2531377, PubMed:2972276, PubMed:16254193).
Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L033R | anti-MME immunotoxin SN5d (Fab)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L034R | anti-MME immunotoxin SN5d (IgG)-RTA | Cytotoxicity assay, Functional assay |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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