Recombinant Mouse Anti-MME Antibody (VS4-CJ37) (CAT#: VS4-CJ37)
This mouse anti-MME antibody is a product that recognizes human, mouse, rat MME. The immunogen of this antibody is a synthetic peptide corresponding to MME. The mAb has been tested for use in ELISA, Immunohistochemistry (1:100-1:200).
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Normal Tissue
RNA Expression
Figure 1 Duodenum
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
Figure 2 High expression in small intestine
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
Figure 3 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
Specifications
- Immunogen
- Synthetic Peptide
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse, Rat MME
- Species Reactivity
- Human, Mouse, Rat
- Applications
- ELISA, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Immunogen affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Immunohistochemistry (1:100-1:200).
Target
- Alternative Names
- NEP; SFE; CD10; CALLA; CMT2T; SCA43
- Gene ID
- 4311
- UniProt ID
- P08473
- Long Name
- Membrane metalloendopeptidase
- Sequence Similarities
- Belongs to the peptidase M13 family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Myristoylation is a determinant of membrane targeting.
Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
- Protein Refseq
- NP_000893.2; NP_009218.2; NP_009219.2
- Function
- Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:6349683, PubMed:6208535, PubMed:15283675, PubMed:8168535).
Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991).
Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535).
Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:6349683, PubMed:15283675).
Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:2531377, PubMed:2972276, PubMed:16254193).
Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1454z | Mouse Anti-MME Recombinant Antibody (clone 24C6) | WB, FC, IF, IHC | Mouse IgG1, κ |
| MOB-0276MZ | Recombinant Mouse Anti-Human Membrane Metallo-endopeptidase Antibody (clone 57D7) | IHC | Mouse antibody |
| MRO-0266-CN | Recombinant Rabbit Anti-MME Monoclonal Antibody (CBACN-103) | WB, FC, IHC, IF | Rabbit IgG |
| HPAB-0311-YJ | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5) | IHC, ELISA, WB | Mouse IgG2a |
| ZG-0001U | Rabbit Anti-MME Recombinant Antibody (clone 10G11) | ELISA, IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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