Recombinant Anti-MME Vesicular Antibody, EV Displayed (VS-0425-YC720)
CAT#: VS-0425-YC720
The Recombinant Anti-MME Vesicular Antibody, EV Displayed (VS-0425-YC720) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MME-expressed cells or tissues. MME is a type II transmembrane glycoprotein used as a cell surface marker in acute lymphocytic leukemia diagnosis. Also known as a neutral endopeptidase, it cleaves various peptide hormones and is found on normal tissues beyond leukemic cells.
Gene Expression
Normal Tissue
Figure 1 Duodenum
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
Normal Tissue
Figure 2 High expression in small intestine
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MME
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Membrane metalloendopeptidase
- Molecular Function
- Hydrolase, Metalloprotease, Protease
- Cellular Localization
- Plasma membrane, Centrosome, Basal body, Cytosol
- Introduction
- The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
- Alternative Names
- CALLA, CD10, NEP
- Gene ID
- 4311
- UniProt ID
- P08473
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| MOR-2246 | Hi-Affi™ Recombinant Rabbit Anti-MME Monoclonal Antibody (DS2246AB) | ICC, IF, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244-FY-S(P) | Recombinant Human Anti-MME Antibody scFv Fragment | F | Human scFv |
| HPAB-0311-YJ-S(P) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); scFv Fragment | IHC, ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244-FY-F(E) | Recombinant Human Anti-MME Antibody Fab Fragment | F | Human Fab |
| HPAB-0311-YJ-F(E) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); Fab Fragment | IHC, ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX776 | Mouse Anti-MME Recombinant Antibody (clone 7C7-1G5-10E3) | IHC | Mouse IgG1 |
| VS3-FY227 | Recombinant Mouse Anti-MME Antibody (clone 1H8C10) | ELISA, WB, FC, IHC | Mouse IgG2b |
| VS3-FY228 | Recombinant Mouse Anti-MME Antibody (clone 2D12B3) | ELISA, FC | Mouse IgG1 |
| VS3-FY229 | Recombinant Mouse Anti-MME Antibody (clone 2D12D1) | ELISA, FC | Mouse IgG1 |
| VS3-FY230 | Recombinant Mouse Anti-MME Antibody (clone 5C11D6) | ELISA, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY1083 | Mouse Anti-MME Recombinant Antibody (clone 307CT12.12.5) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC682 | AbPlus™ Anti-MME Magnetic Beads (VS-0724-YC682) | IP, Protein Purification | |
| VS-0724-YC779 | AbPlus™ Anti-MME Magnetic Beads (VS-0724-YC779) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4431 | Anti-MME Immunohistochemistry Kit | IHC | |
| VS-0525-XY4432 | Anti-Mouse MME Immunohistochemistry Kit | IHC | |
| VS-0525-XY4433 | Anti-Rat MME Immunohistochemistry Kit | IHC |
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