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    Recombinant Anti-MTDH Vesicular Antibody, EV Displayed (VS-0425-YC556) (CAT#: VS-0425-YC556)

    The Recombinant Anti-MTDH Vesicular Antibody, EV Displayed (VS-0425-YC556) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MTDH-expressed cells or tissues. MTDH is involved in pathways such as C-MYC activation and linked to diseases like gallbladder adenocarcinoma. MTDH assists in double-stranded RNA binding.

    Specific Inquiry
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to endoplasmic reticulum.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/10932/if_selected.jpg
    Figure 2 IF staining of human cell line U-2 OS
    Figure 2 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68204/1894_H7_3_selected.jpg
    Figure 3 IHC staining of human small intestine
    Figure 3 IHC staining of human small intestine
    (Immunohistochemical staining of human small intestine shows cytoplasmic positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/10932/158178_A_4_2_selected.jpg
    Figure 4 IHC staining of human cerebral corte
    Figure 4 IHC staining of human cerebral corte
    (Immunohistochemical staining of human cerebral cortex shows strong positivity.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68204/ihc_selected.jpg
    Figure 5 IHC staining of human smooth muscle
    Figure 5 IHC staining of human smooth muscle
    (Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/68205/ihc_selected.jpg
    Normal Tissue
    Figure 6 Colon
    Figure 6 Colon
    (Endothelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/10932/158178_A_7_3.jpg
    Figure 7 Liver
    Figure 7 Liver
    (Hepatocytes
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/10932/158178_A_7_4.jpg
    Figure 8 Kidney
    Figure 8 Kidney
    (Cells in glomeruli
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Cells in tubules
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/10932/158178_A_7_5.jpg
    Figure 9 Testis
    Figure 9 Testis
    (Leydig cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Spermatogonia cells
    Staining: High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/10932/158178_A_6_6.jpg
    Figure 10 Lymph node
    Figure 10 Lymph node
    (Germinal center cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/10932/158178_A_8_8.jpg
    RNA Expression
    Figure 11 RNA cell line category: Low cell line specificity
    Figure 11 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000147649-MTDH

    Recombinant Antibody

    • Application
    • ELISA, FC, Cell-uptake
    • Product Type
    • Ab-Fc-EVs
    • Antibody Quantification (Ab/EV)
    • ~100 Ab/EV
    • Target
    • MTDH
    • Host Animal
    • Mouse
    • Antibody Isotype
    • IgG
    • Species Reactivity
    • Human
    • Expression Cell
    • Mammalian cell

    Engineered EVs

    • EV-sorting domain
    • CD63
    • Fc-binding domain
    • Protein A
    • EV Size
    • 30~150 nm
    • Producing Cell
    • HEK293F
    • Isolation Method
    • Gradient centrifugation
    • Purification
    • qEV size exclusion chromatography
    • Concentration
    • 1 x 10¹⁰
    • Size
    • 1 mL
    • Buffer
    • PBS
    • Storage
    • Store at -80°C for 12 months

    Target

    • Full Name
    • Metadherin
    • Cellular Localization
    • Endoplasmic reticulum
    • Introduction
    • MTDH (Metadherin) is a Protein Coding gene. Diseases associated with MTDH include Gallbladder Adenocarcinoma and Nervous System Disease. Among its related pathways are Validated targets of C-MYC transcriptional activation and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding.
    • Alternative Names
    • 3D3, AEG-1, LYRIC

    Downloads

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    MOB-678 Recombinant Anti-human MTDH Antibody ELISA, WB, IF, FuncS IgG
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    VS3-FY969 Recombinant Mouse Anti-MTDH Antibody (clone 1F3A3) ELISA, WB, IHC, ICC, FC Mouse IgG1
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