Recombinant Anti-NOTCH3 Vesicular Antibody, EV Displayed (VS-0425-YC122)
CAT#: VS-0425-YC122
The Recombinant Anti-NOTCH3 Vesicular Antibody, EV Displayed (VS-0425-YC122) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NOTCH3-expressed cells or tissues. The NOTCH3 is the third discovered human homolog of the Drosophila melanogaster type I membrane protein notch. In Drosophila, its interaction with cell-bound ligands establishes an essential intercellular signaling pathway for neural development. Mutations in this gene are identified as the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, cytosol & actin filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44392/if_selected.jpg
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NOTCH3
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Notch receptor 3
- Biological Process
- Differentiation, Notch signaling pathway, Transcription, Transcription regulation
- Molecular Function
- Activator, Developmental protein, Receptor
- Cellular Localization
- Nucleoplasm, Plasma membrane
- Introduction
- This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
- Alternative Names
- CADASIL, CASIL
- Gene ID
- 4854
- UniProt ID
- Q9UM47
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Related Diseases
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Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "NOTCH3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1929z | Mouse Anti-NOTCH3 Recombinant Antibody (clone 22H2) | WB, ELISA | Mouse IgG2a |
| HPAB-0754-WJ | Human Anti-NOTCH3 Recombinant Antibody (clone N37) | ELISA | Human IgG |
| HPAB-1010WJ | Human Anti-NOTCH3 Recombinant Antibody (clone N3WCR3P1B12) | ELISA, WB, FC | Human IgG |
| HPAB-1011WJ | Human Anti-NOTCH3 Recombinant Antibody (clone hN3S2_160) | ELISA, WB, FC | Human IgG |
| VS3-QX826 | Mouse Anti-NOTCH3 Recombinant Antibody (clone 487CT6.9.2) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-554MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-554MZ) | FuncS, Inhib, WB | Human IgG |
| TAB-555MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-555MZ) | FC, FuncS, Inhib, WB | Human IgG |
| TAB-559MZ | Anti-Human NOTCH3 Recombinant Antibody (TAB-559MZ) | FC, Inhib, FuncS | Human antibody |
| TAB-560MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-560MZ) | FC, FACS, FuncS | Human IgG1, κ |
| TAB-561MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-561MZ) | FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-556MZ | Mouse Anti-NOTCH3 Recombinant Antibody (TAB-556MZ) | ELISA, Inhib, WB, Neut | Mouse IgG1, κ |
| TAB-562MZ | Anti-Human NOTCH3 Recombinant Antibody (TAB-562MZ) | ELISA, FuncS | |
| TAB-563MZ | Anti-Human NOTCH3 Recombinant Antibody (TAB-563MZ) | ELISA, FuncS | |
| TAB-556MZ-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-556MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-562MZ-S(P) | Anti-Human NOTCH3 Recombinant Antibody scFv Fragment (TAB-562MZ-S(P)) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-557MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-557MZ) | Inhib, Neut | Chimeric (mouse/human) IgG1 |
| TAB-557MZ-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-557MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-557MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-557MZ-F(E)) | ELISA, WB | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-558MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-558MZ) | Inhib, Neut | Humanized IgG1 |
| TAB-558MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-558MZ-S(P)) | ELISA, WB | Humanized scFv |
| TAB-558MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-558MZ-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0282-YC-F(E) | Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23); Fab Fragment | ELISA, IHC, WB | Mouse Fab |
| HPAB-0283-YC-F(E) | Mouse Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-0283-YC-F(E)) | ELISA, IHC, WB | Mouse Fab |
| HPAB-0284-YC-F(E) | Mouse Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-0284-YC-F(E)) | ELISA, IHC, WB | Mouse Fab |
| HPAB-M0577-YC-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-M0577-YC-F(E)) | FC, WB, Inhib | Human Fab |
| HPAB-M0578-YC-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-M0578-YC-F(E)) | FC, WB, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0754-WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N37); scFv Fragment | ELISA | Human scFv |
| HPAB-1010WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N3WCR3P1B12); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-1011WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone hN3S2_160); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-1012WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N3LHCS_18); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-1013WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N1wc561); scFv Fragment | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC81 | Rabbit Anti-NOTCH3 Antibody (VS-0924-YC81) - Cancer Stem Cell Marker | IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY161 | Human Anti-NOTCH3 scFv-Fc Chimera (VS-0425-FY161) | ELISA, FC, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4910 | Anti-NOTCH3 Immunohistochemistry Kit | IHC |
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