Recombinant Anti-NOTCH4 Vesicular Antibody, EV Displayed (VS-0425-YC650)
CAT#: VS-0425-YC650
The Recombinant Anti-NOTCH4 Vesicular Antibody, EV Displayed (VS-0425-YC650) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NOTCH4-expressed cells or tissues. NOTCH4 is a NOTCH family member, important for intercellular signaling, influencing vascular, renal, and hepatic development.
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NOTCH4
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Notch receptor 4
- Biological Process
- Differentiation, Host-virus interaction, Notch signaling pathway, Transcription, Transcription regulation
- Molecular Function
- Activator, Developmental protein, Receptor
- Introduction
- This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
- Alternative Names
- INT3
- Gene ID
- 4855
- UniProt ID
- Q99466
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Related Diseases
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Datasheet
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COA
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See other products for "NOTCH4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1787CQ | Recombinant Hamster Anti-Notch4 Antibody (HMN4-14) | BL, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2474 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH4 Monoclonal Antibody (DS2474AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-CN | Mouse Anti-NOTCH4 Recombinant Antibody (HPAB-0066-CN) | Neut | Mouse IgG1, κ |
| HPAB-0068-CN | Human Anti-NOTCH4 Recombinant Antibody (HPAB-0068-CN) | Neut, IF | Humanized IgG2 |
| HPAB-0067-CN | Human Anti-NOTCH4 Recombinant Antibody (HPAB-0067-CN) | Neut | Chimeric (mouse/human) IgG2, κ |
| MRO-1103-CN | Recombinant Rabbit Anti-NOTCH4 Monoclonal Antibody (JM101-05) | WB, FC | Rabbit IgG |
| VS3-WK529 | Rabbit Anti-NOTCH4 Recombinant Antibody (clone JM101-05) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-CN-S(P) | Mouse Anti-NOTCH4 Recombinant Antibody; scFv Fragment (HPAB-0066-CN-S(P)) | Neut | Mouse scFv |
| HPAB-0068-CN-S(P) | Human Anti-NOTCH4 Recombinant Antibody; scFv Fragment (HPAB-0068-CN-S(P)) | Neut, IF | Human scFv |
| HPAB-N0194-YC-S(P) | Human Anti-NOTCH4 Recombinant Antibody (clone GLA-S4F18); scFv Fragment | FC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-CN-F(E) | Mouse Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0066-CN-F(E)) | Neut | Mouse Fab |
| HPAB-0068-CN-F(E) | Human Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0068-CN-F(E)) | Neut, IF | Human Fab |
| HPAB-0067-CN-F(E) | Human Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0067-CN-F(E)) | Neut | Human Fab |
| HPAB-N0194-YC-F(E) | Human Anti-NOTCH4 Recombinant Antibody (clone GLA-S4F18); Fab Fragment | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY162 | Human Anti-NOTCH4 scFv-Fc Chimera (VS-0425-FY162) | FC | Human IgG1, scFv-Fc |
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