Recombinant Anti-OSMR Vesicular Antibody, EV Displayed (VS-0425-YC22)
CAT#: VS-0425-YC22
The Recombinant Anti-OSMR Vesicular Antibody, EV Displayed (VS-0425-YC22) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to OSMR-expressed cells or tissues. The OSMR is a protein in the type I cytokine receptor family, forming receptors that transduce signaling from cytokines like oncostatin M and interleukin 31. Mutations in this gene are linked to familial primary localized cutaneous amyloidosis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17278/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17278/40086_B_9_5.jpg
Normal Tissue
Figure 3 Cerebellum
Cells in granular layer Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17278/40086_B_7_8.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17278/40086_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17278/40086_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17278/40086_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17278/40086_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC TERT1, GAMG, HSkMC, U-2197)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145623-OSMR
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- OSMR
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Oncostatin M receptor
- Molecular Function
- Receptor
- Cellular Localization
- Nucleoli
- Introduction
- This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- OSMRB, OSMRbeta
- Gene ID
- 9180
- UniProt ID
- Q99650
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "OSMR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0866CL-S(P) | Human Anti-OSMR Recombinant Antibody; scFv Fragment (TAB-0866CL-S(P)) | ELISA | Human scFv |
| TAB-0867CL-S(P) | Human Anti-OSMR Recombinant Antibody; scFv Fragment (TAB-0867CL-S(P)) | ELISA | Human scFv |
| TAB-0866CL-F(E) | Human Anti-OSMR Recombinant Antibody; Fab Fragment (TAB-0866CL-F(E)) | ELISA | Human Fab |
| TAB-0867CL-F(E) | Human Anti-OSMR Recombinant Antibody; Fab Fragment (TAB-0867CL-F(E)) | ELISA | Human Fab |
| TAB-0868CL-F(E) | Human Anti-OSMR Recombinant Antibody; Fab Fragment (TAB-0868CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4353 | Hi-Affi™ Recombinant Rabbit Anti-OSMR Monoclonal Antibody (SI443DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0723-WK19 | Human Anti-OSMR Recombinant Antibody (clone Vixarelimab) | FC | Human IgG4, lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC413 | AbPlus™ Anti-OSMR Magnetic Beads (VS-0724-YC413) | IP, Protein Purification |
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