Recombinant Anti-PPP1R3A Vesicular Antibody, EV Displayed (VS-0425-YC374)
CAT#: VS-0425-YC374
The Recombinant Anti-PPP1R3A Vesicular Antibody, EV Displayed (VS-0425-YC374) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PPP1R3A-expressed cells or tissues. The PPP1R3A is a regulatory subunit of glycogen-bound phosphatase, enhancing the dephosphorylation of glycogen-bound substrates.
Gene Expression
Normal Tissue
Figure 1 Skeletal muscle
Myocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70440/166344_B_2_6.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154415-PPP1R3A
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PPP1R3A
- Host Animal
- Human
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Protein phosphatase 1 regulatory subunit 3A
- Biological Process
- Carbohydrate metabolism, Glycogen metabolism
- Introduction
- The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase.
- Alternative Names
- GM, PPP1R3
- Gene ID
- 5506
- UniProt ID
- Q16821
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-1406-FY | Human Anti-PPP1R3A Recombinant Antibody (clone 34E1) | WB, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1406-FY-F(E) | Human Anti-PPP1R3A Recombinant Antibody (clone 34E1); scFv Fragment | WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1406-FY-S(P) | Human Anti-PPP1R3A Recombinant Antibody (clone 34E1); Fab Fragment | WB, ELISA | Human Fab |
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