Recombinant Mouse Anti-PPP4C Antibody (VS4-CJ86)
CAT#: VS4-CJ86
This mouse anti-PPP4C antibody is a product that recognizes human, dog, mouse, bovine, rat PPP4C. The immunogen of this antibody is recombinant full length protein (307aa) of human PPP4C. The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunohistochemistry (1:50-1:500), Immunocytochemistry (1:50-1:200).
Specifications
- Immunogen
- Recombinant full length protein (307aa) of human PPP4C.
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human, Dog, Mouse, Bovine, Rat PPP4C
- Species Reactivity
- Human, Dog, Mouse, Bovine, Rat
- Applications
- ELISA, WB, IHC, ICC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.
- Preservative
- 0.2% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunohistochemistry (1:50-1:500), Immunocytochemistry (1:50-1:200).
Target
- Alternative Names
- PP-X; PP4; PP4C; PPH3; PPP4; PPX
- Gene ID
- 5531
- UniProt ID
- P60510
- Long Name
- Protein phosphatase 4 catalytic subunit
- Sequence Similarities
- Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
- Cellular Localization
- Nucleus, Cytoplasm, Cytoskeleton
- Post Translation Modifications
- Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
- Protein Refseq
- NP_001290432.1; NP_001290433.1; NP_001290435.1
- Function
- Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity).
In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
See other products for "PPP4C"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1628CT | Recombinant Mouse anti-Human PPP4C Monoclonal antibody (3) | ELISA, WB | |
| ZG-0393C | Mouse Anti-PPP4C Recombinant Antibody (ZG-0393C) | WB, IHC, IF | Mouse IgG |
| VS3-CJ75 | Mouse Anti-PPP4C Recombinant Antibody (VS3-CJ75) | WB, ELISA | Mouse IgG |
| VS3-FY1608 | Rabbit Anti-PPP4C Recombinant Antibody (clone R05-4F9) | WB | Rabbit IgG |
| VS7-0425-WR670 | Mouse Anti-PPP4C Recombinant Antibody (VS7-0425-WR670) | WB, IHC-P, IF, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1005 | AbPlus™ Anti-PPP4C Magnetic Beads (VS-0724-YC1005) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1728 | Anti-PPP4C Immunohistochemistry Kit | IHC |
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