Recombinant Anti-PSEN2 Vesicular Antibody, EV Displayed (VS-0425-YC90)
CAT#: VS-0425-YC90
The Recombinant Anti-PSEN2 Vesicular Antibody, EV Displayed (VS-0425-YC90) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PSEN2-expressed cells or tissues. The PSEN2 is a protein involved in APP processing and gamma-secretase regulation, with mutations linked to Alzheimer's disease.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143801-PSEN2
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PSEN2
- Host Animal
- Rabbit
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Presenilin 2
- Biological Process
- Notch signaling pathway
- Molecular Function
- Hydrolase, Protease
- Introduction
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.
- Alternative Names
- AD4; PS2; AD3L; STM2; CMD1V
- Gene ID
- 5664
- UniProt ID
- P49810
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Datasheet
MSDS
COA
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See other products for "PSEN2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2034-VHH | Recombinant Anti-Human PSEN2 VHH Single Domain Antibody | ICC, ChiP, FC, FA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2278z | Mouse Anti-PSEN2 Recombinant Antibody (clone 26D11) | WB, ELISA, ICC, IF, IHC | Mouse IgG1 |
| MOB-2410CT | Recombinant Mouse anti-Human PSEN2 Monoclonal antibody (QQJ) | WB, IF, ELISA | |
| VS3-FY1205 | Recombinant Rabbit Anti-PSEN2 Antibody (clone R02-5B8) | WB, IP | Rabbit IgG |
| VS3-WK1985 | Rabbit Anti-PSEN2 (pS330) Recombinant Antibody (clone R01-5C9) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0774MZ | Chicken Anti-PSEN2 Polyclonal IgY | N/A | Chicken antibody |
| BRD-1140MZ | Chicken Anti-Presenilin 2 Polyclonal IgY | WB, ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2884 | Hi-Affi™ Recombinant Rabbit Anti-PSEN2 Monoclonal Antibody (DS2884AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY414 | Mouse Anti-NHP PSEN2 Recombinant Antibody (clone APS 21) | WB, ICC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5765 | Anti-PSEN2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5766 | Anti-Mouse PSEN2 Immunohistochemistry Kit | IHC |
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