Recombinant Anti-RAMP1 Vesicular Antibody, EV Displayed (VS-0425-YC438)
CAT#: VS-0425-YC438
The Recombinant Anti-RAMP1 Vesicular Antibody, EV Displayed (VS-0425-YC438) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to RAMP1-expressed cells or tissues. The RAMP1 is a modifying protein for calcitonin receptors, involved in glycosylation and CGRP receptor maturation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & nuclear membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57814/1020_B6_3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, HDLM-2, PC-3, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132329-RAMP1
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- RAMP1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Receptor activity modifying protein 1
- Biological Process
- Transport
- Molecular Function
- Receptor
- Cellular Localization
- Nucleoplasm, Nuclear membrane
- Introduction
- The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
- Gene ID
- 10267
- UniProt ID
- O60894
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Datasheet
MSDS
COA
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| MOB-2606z | Mouse Anti-RAMP1 Recombinant Antibody (clone 32A11) | WB, ELISA, IP | Mouse IgG2b, κ |
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| NS-068CN-S(P) | Mouse Anti-RAMP1 Recombinant Antibody (clone JF2); scFv Fragment | ELISA, WB | Mouse scFv |
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| CAT | Product Name | Application | Type |
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| NS-069CN | Mouse Anti-RAMP1 Recombinant Antibody (clone JB3) | ELISA, WB, Apop, FuncS | Mouse IgM |
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