Recombinant Anti-ROBO4 Vesicular Antibody, EV Displayed (VS-0425-YC496) (CAT#: VS-0425-YC496)
The Recombinant Anti-ROBO4 Vesicular Antibody, EV Displayed (VS-0425-YC496) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ROBO4-expressed cells or tissues. ROBO4 facilitates cell-cell adhesion and endothelial barrier formation. ROBO4 is associated with aortic valve disease and pre-eclampsia.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65212/1589_F7_2_selected.jpg
(Immunofluorescent staining of human cell line PC-3 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65212/1589_F7_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154133-ROBO4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154133-ROBO4
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ROBO4
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Roundabout guidance receptor 4
- Biological Process
- Angiogenesis, Differentiation
- Molecular Function
- Developmental protein, Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- Predicted to enable cell-cell adhesion mediator activity. Involved in establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3. Biomarker of pre-eclampsia and thyroid gland carcinoma.
- Alternative Names
- ECSM4, FLJ20798, MRB
- Gene ID
- 54538
- UniProt ID
- Q8WZ75
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-329CT | Mouse Anti-Robo4 Recombinant Antibody (TAB-329CT) | WB, ELISA, FC, IHC | Mouse IgG2a |
| TAB-329CT-S(P) | Mouse Anti-Robo4 Recombinant Antibody; scFv Fragment (TAB-329CT-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
| TAB-329CT-F(E) | Mouse Anti-Robo4 Recombinant Antibody; Fab Fragment (TAB-329CT-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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