Recombinant Mouse Anti-S100A1 Antibody (clone 9E8-8B8-9B4) (CAT#: VS3-FY1292)
This product is a recombinant mouse antibody that recognizes S100A1. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 9E8-8B8-9B4 is specific for human S100A1. The antigen is synthetic peptide derived from human s100.
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IHC-P
Figure 1. Recombinant Mouse Anti-S100A1 Antibody (clone 9E8-8B8-9B4) in IHC-P.
Immunohistochemical analysis of paraffin-embedded malignant melanoma using S100A1 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Specifications
- Immunogen
- Synthetic peptide derived from human S100.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human S100A1
- Species Reactivity
- Human
- Clone
- 9E8-8B8-9B4
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- S100 Calcium Binding Protein A1; S100 Calcium-Binding Protein A1; S-100 Protein Subunit Alpha; S-100 Protein Alpha Chain; S100A; S100 Protein, Alpha Polypeptide
- Gene ID
- 6271
- UniProt ID
- P23297
- Sequence Similarities
- Belongs to the S-100 family.
- Cellular Localization
- Cytoplasm, Mitochondrion, Sarcoplasmic reticulum
- Post Translation Modifications
- Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.
- Protein Refseq
- NP_006262.1
- Function
- Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).
In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007).
These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290).
Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600).
Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).
Recommended Products
Secondary Antibody
Isotype Control
Reconstitution Buffer
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3941z | Mouse Anti-S100A1 Recombinant Antibody (clone 9H7) | WB, ELISA, IHC | Mouse IgG1 |
| MOB-1444MZ | Recombinant Mouse Anti-Human S100A1 Antibody (clone 9C20) | ELISA, ICC/IF, WB, sELISA | Mouse antibody |
| ZG-0356U | Rabbit Anti-S100A1 Recombinant Antibody (clone D28-E) | IHC-P | Rabbit IgG |
| VS3-WK1918 | Recombinant Rabbit Anti-S100A1 Capture Antibody (clone R39-3P-7) | ELISA | Rabbit IgG |
| VS3-WK1919 | Recombinant Rabbit Anti-S100A1 Detection Antibody (clone R68-6V-1) | ELISA | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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