Recombinant Anti-SEMA4D Vesicular Antibody, EV Displayed (VS-0425-YC533)
CAT#: VS-0425-YC533
The Recombinant Anti-SEMA4D Vesicular Antibody, EV Displayed (VS-0425-YC533) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SEMA4D-expressed cells or tissues. SEMA4D is a protein involved in semaphorin signaling and related pathways. Diseases like hemorrhagic fever and osteonecrosis are associated with SEMA4D, which exhibits receptor binding and signaling activities.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human skeletal muscle
Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23277/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187764-SEMA4D
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SEMA4D
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Semaphorin 4D
- Biological Process
- Differentiation, Neurogenesis
- Molecular Function
- Developmental protein, Receptor
- Cellular Localization
- Vesicles, Plasma membrane, Basal body, Nucleoplasm, Primary cilium transition zone, Centrosome
- Introduction
- SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Hemorrhagic Fever With Renal Syndrome and Osteonecrosis Of The Jaw. Among its related pathways are Development Slit-Robo signaling and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include receptor binding and transmembrane signaling receptor activity. An important paralog of this gene is SEMA4C.
- Alternative Names
- C9orf164, CD100, coll-4, FLJ39737, SEMAJ
- Gene ID
- 10507
- UniProt ID
- Q92854
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-429CT | Humanized Anti-SEMA4D Recombinant Antibody (TAB-429CT) | WB | Humanized IgG |
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| TAB-429CT-S(P) | Humanized Anti-SEMA4D Recombinant Antibody; scFv Fragment (TAB-429CT-S(P)) | WB, ELISA, FC, BL | Humanized scFv |
| TAB-430CT-S(P) | Humanized Anti-SEMA4D Recombinant Antibody; scFv Fragment (TAB-430CT-S(P)) | WB, ELISA, FC, BL | Humanized scFv |
| TAB-429CT-F(E) | Humanized Anti-SEMA4D Recombinant Antibody; Fab Fragment (TAB-429CT-F(E)) | WB, ELISA, FC, BL | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1861CT | Recombinant Mouse anti-Human SEMA4D Monoclonal antibody (244-2D7) | ELISA, FC, IP | |
| HPAB-AP440-YC | Mouse Anti-SEMA4D Recombinant Antibody (HPAB-AP440-YC) | ELISA, Block, Neut, FuncS | Mouse IgG2b |
| HPAB-AP442-YC | Mouse Anti-SEMA4D Recombinant Antibody (HPAB-AP442-YC) | ELISA, Block, Neut, FuncS | Mouse IgG2b |
| VS4-CJ110 | Recombinant Human Anti-SEMA4D Antibody (clone 5D12) | ELISA, FC | Human IgG4 (S228P) |
| VS4-CJ111 | Recombinant Mouse Anti-SEMA4D Antibody (clone 10E12E10) | ELISA, WB, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3206 | Hi-Affi™ Recombinant Rabbit Anti-SEMA4D Monoclonal Antibody (DS3206AB) | WB, IHC, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0049-WJ-F(E) | Mouse Anti-SEMA4D Recombinant Antibody; Fab Fragment (HPAB-0049-WJ-F(E)) | FC, ELISA | Mouse Fab |
| HPAB-AP440-YC-F(E) | Mouse Anti-SEMA4D Recombinant Antibody; Fab Fragment (HPAB-AP440-YC-F(E)) | ELISA, Block, Neut, FuncS | Mouse Fab |
| HPAB-AP442-YC-F(E) | Mouse Anti-SEMA4D Recombinant Antibody; Fab Fragment (HPAB-AP442-YC-F(E)) | ELISA, Block, Neut, FuncS | Mouse Fab |
| HPAB-0934WJ-F(E) | Mouse Anti-SEMA4D Recombinant Antibody; Fab Fragment (HPAB-0934WJ-F(E)) | Neut | Mouse Fab |
| HPAB-0935WJ-F(E) | Human Anti-SEMA4D Recombinant Antibody; Fab Fragment (HPAB-0935WJ-F(E)) | Neut, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP440-YC-S(P) | Mouse Anti-SEMA4D Recombinant Antibody; scFv Fragment (HPAB-AP440-YC-S(P)) | ELISA, Block, Neut, FuncS | Mouse scFv |
| HPAB-AP442-YC-S(P) | Mouse Anti-SEMA4D Recombinant Antibody; scFv Fragment (HPAB-AP442-YC-S(P)) | ELISA, Block, Neut, FuncS | Mouse scFv |
| HPAB-AP443-YC-S(P) | Human Anti-SEMA4D Recombinant Antibody; scFv Fragment (HPAB-AP443-YC-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0934WJ-S(P) | Mouse Anti-SEMA4D Recombinant Antibody; scFv Fragment (HPAB-0934WJ-S(P)) | Neut | Mouse scFv |
| HPAB-0935WJ-S(P) | Human Anti-SEMA4D Recombinant Antibody; scFv Fragment (HPAB-0935WJ-S(P)) | Neut, ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY70 | Mouse Anti-NHP SEMA4D Recombinant Antibody (clone A8) | IF, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY197 | CytoStream™ Rat Anti-SEMA4D Recombinant Antibody (clone BMA-12) | FC | Rat IgG2a, lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6444 | Anti-SEMA4D Immunohistochemistry Kit | IHC |
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