Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455) (CAT#: VS-0425-YC455)
The Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIGLEC15-expressed cells or tissues. The SIGLEC15 is predicted to regulate cytoskeleton organization and osteoclast development, located in the membrane.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression

Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53509/1201_B2_5_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53509/1201_B2_5_selected.jpg

Figure 2 RNA cell line category: Cell line enriched (U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197046-SIGLEC15/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197046-SIGLEC15/subcellular
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SIGLEC15
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Sialic acid binding Ig like lectin 15
- Cellular Localization
- Nucleoplasm, Golgi apparatus
- Introduction
- Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane.
- Alternative Names
- CD33L3, HsT1361
- Gene ID
- 284266
- UniProt ID
- Q6ZMC9
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-904 | Recombinant Anti-human SIGLEC15 Antibody | WB, IP, FuncS | IgG |
HPAB-AP456-YC | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2b/L3b) | Inhib, FuncS | Humanized (rat/human) IgG2 |
HPAB-AP457-YC | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2c/L1) | Inhib, FuncS | Humanized (rat/human) IgG2 |
HPAB-AP458-YC | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2c/L2b) | Inhib, FuncS | Humanized (rat/human) IgG2 |
HPAB-AP459-YC | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2c/L3b) | Inhib, FuncS | Humanized (rat/human) IgG2 |
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For Research Use Only. Not For Clinical Use.
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