Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455) (CAT#: VS-0425-YC455)
The Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIGLEC15-expressed cells or tissues. The SIGLEC15 is predicted to regulate cytoskeleton organization and osteoclast development, located in the membrane.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53509/1201_B2_5_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53509/1201_B2_5_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197046-SIGLEC15/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197046-SIGLEC15/subcellular
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SIGLEC15
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Sialic acid binding Ig like lectin 15
- Cellular Localization
- Nucleoplasm, Golgi apparatus
- Introduction
- Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane.
- Alternative Names
- CD33L3, HsT1361
- Gene ID
- 284266
- UniProt ID
- Q6ZMC9
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IgG Antibody Products
Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-904-F(E) | Recombinant Anti-human SIGLEC15 Antibody Fab Fragment | IF, Neut, FuncS | Fab |
| HPAB-AP449-YC-F(E) | Rat Anti-SIGLEC15 Recombinant Antibody (clone 24A3); Fab Fragment | Inhib, FuncS | Rat Fab |
| HPAB-AP450-YC-F(E) | Human Anti-SIGLEC15 Recombinant Antibody (clone ch24A3); Fab Fragment | Inhib, FuncS | Chimeric (rat/human) Fab |
| HPAB-AP451-YC-F(E) | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L1); Fab Fragment | Inhib, FuncS | Humanized (rat/human) Fab |
| HPAB-AP452-YC-F(E) | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L2); Fab Fragment | Inhib, FuncS | Humanized (rat/human) Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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