Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455)
CAT#: VS-0425-YC455
The Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIGLEC15-expressed cells or tissues. The SIGLEC15 is predicted to regulate cytoskeleton organization and osteoclast development, located in the membrane.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53509/1201_B2_5_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197046-SIGLEC15/subcellular
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Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SIGLEC15
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Sialic acid binding Ig like lectin 15
- Cellular Localization
- Nucleoplasm, Golgi apparatus
- Introduction
- Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane.
- Alternative Names
- CD33L3, HsT1361
- Gene ID
- 284266
- UniProt ID
- Q6ZMC9
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Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-904-S(P) | Recombinant Anti-human SIGLEC15 Antibody scFv Fragment | WB, ELISA, IHC, FuncS | scFv |
| HPAB-AP449-YC-S(P) | Rat Anti-SIGLEC15 Recombinant Antibody (clone 24A3); scFv Fragment | Inhib, FuncS | Rat scFv |
| HPAB-AP450-YC-S(P) | Human Anti-SIGLEC15 Recombinant Antibody (clone ch24A3); scFv Fragment | Inhib, FuncS | Rat scFv |
| HPAB-AP451-YC-S(P) | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L1); scFv Fragment | Inhib, FuncS | Humanized (rat/human) scFv |
| HPAB-AP452-YC-S(P) | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L2); scFv Fragment | Inhib, FuncS | Humanized (rat/human) scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-568CL | Human Anti-SIGLEC15 Recombinant Antibody (TAB-568CL) | ELISA | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-441CT | Chimeric Anti-Siglec15 Recombinant Antibody (TAB-441CT) | ELISA, FC, BL | Chimeric antibody (mouse/human) |
| TAB-442CT | Chimeric Anti-Siglec15 Recombinant Antibody (TAB-442CT) | ELISA, FC, BL | Chimeric antibody (mouse/human) |
| TAB-443CT | Chimeric Anti-Siglec15 Recombinant Antibody (TAB-443CT) | ELISA, FC, BL | Chimeric antibody (mouse/human) |
| TAB-444CT | Chimeric Anti-Siglec15 Recombinant Antibody (TAB-444CT) | ELISA, FC, BL | Chimeric antibody (mouse/human) |
| TAB-445CT | Chimeric Anti-Siglec15 Recombinant Antibody (TAB-445CT) | ELISA, FC, BL | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-447CT | Human Anti-Siglec15 Recombinant Antibody (TAB-447CT) | WB, ELISA, FC | Human IgG |
| TAB-448CT | Human Anti-Siglec15 Recombinant Antibody (TAB-448CT) | WB, ELISA, FC | Human IgG |
| TAB-447CT-S(P) | Human Anti-Siglec15 Recombinant Antibody; scFv Fragment (TAB-447CT-S(P)) | WB, ELISA, FC | Human scFv |
| TAB-447CT-F(E) | Human Anti-Siglec15 Recombinant Antibody; Fab Fragment (TAB-447CT-F(E)) | WB, ELISA, FC | Human Fab |
| TAB-448CT-F(E) | Human Anti-Siglec15 Recombinant Antibody; Fab Fragment (TAB-448CT-F(E)) | WB, ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0362MC | Rabbit Anti-Human SIGLEC15 Antibody | WB, IHC-P, P-ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-675-FY-F(E) | Human Anti-SIGLEC15 Recombinant Antibody; Fab Fragment (HPAB-675-FY-F(E)) | ELISA | Human Fab |
| HPAB-AP449-YC-F(E) | Rat Anti-SIGLEC15 Recombinant Antibody (clone 24A3); Fab Fragment | Inhib, FuncS | Rat Fab |
| HPAB-AP450-YC-F(E) | Human Anti-SIGLEC15 Recombinant Antibody (clone ch24A3); Fab Fragment | Inhib, FuncS | Chimeric (rat/human) Fab |
| HPAB-AP451-YC-F(E) | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L1); Fab Fragment | Inhib, FuncS | Humanized (rat/human) Fab |
| HPAB-AP452-YC-F(E) | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L2); Fab Fragment | Inhib, FuncS | Humanized (rat/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP449-YC | Rat Anti-SIGLEC15 Recombinant Antibody (clone 24A3) | Inhib, FuncS | Rat IgG |
| HPAB-AP450-YC | Human Anti-SIGLEC15 Recombinant Antibody (clone ch24A3) | Inhib, FuncS | Chimeric (rat/human) IgG2 |
| HPAB-AP451-YC | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L1) | Inhib, FuncS | Humanized (rat/human) IgG2 |
| HPAB-AP452-YC | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L2) | Inhib, FuncS | Humanized (rat/human) IgG2 |
| HPAB-AP453-YC | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L3) | Inhib, FuncS | Humanized (rat/human) IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY478 | Mouse Anti-NHP SIGLEC15 Recombinant Antibody (clone 3F7F3) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6581 | Anti-SIGLEC15 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6582 | Anti-Human SIGLEC15 Immunohistochemistry Kit | IHC |
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