Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455)

Name: Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455)
SKU: VS-0425-YC455
Rating: 5 (1 reviews)

CAT#: VS-0425-YC455

The Recombinant Anti-SIGLEC15 Vesicular Antibody, EV Displayed (VS-0425-YC455) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIGLEC15-expressed cells or tissues. The SIGLEC15 is predicted to regulate cytoskeleton organization and osteoclast development, located in the membrane.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53509/1201_B2_5_selected.jpg

RNA Expression Figure 2 RNA cell line category: Cell line enriched (U-87 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197046-SIGLEC15/subcellular

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Recombinant Antibody

Application
Block, ELISA, FC, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
SIGLEC15

Host Animal
Mouse

Antibody Isotype
IgG

Species Reactivity
Human, Mouse

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
Protein A

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Sialic acid binding Ig like lectin 15

Cellular Localization
Nucleoplasm, Golgi apparatus

Introduction
Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane.

Alternative Names
CD33L3, HsT1361

Gene ID
284266

UniProt ID
Q6ZMC9

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Downloadable Resources

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Datasheet

Datasheet - VS-0425-YC455.pdf

MSDS

MSDS - VS-0425-YC455.pdf

COA

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