Recombinant Anti-SLC6A2 Vesicular Antibody, EV Displayed (VS-0425-YC62)
CAT#: VS-0425-YC62
The Recombinant Anti-SLC6A2 Vesicular Antibody, EV Displayed (VS-0425-YC62) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SLC6A2-expressed cells or tissues. The SLC6A2 is a transporter involved in neurotransmitter reuptake, related to conditions like alcohol dependence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4057/1669_E2_2_selected.jpg
Normal Tissue
Figure 2 Low expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76311/165710_A_3_3_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78195/163397_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78195/163397_A_8_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000103546-SLC6A2
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SLC6A2
- Host Animal
- Rabbit
- Antibody Isotype
- IgG
- Species Reactivity
- Rat, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Solute carrier family 6 member 2
- Biological Process
- Neurotransmitter transport, Symport, Transport
- Cellular Localization
- Cytosol, Mitochondria
- Introduction
- Enables neurotransmitter transmembrane transporter activity and norepinephrine:sodium symporter activity. Involved in neurotransmitter reuptake and norepinephrine uptake. Acts upstream of or within neurotransmitter transport and response to pain. Predicted to be located in cell surface. Predicted to be active in axon; neuronal cell body membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; lip; nervous system; renal pelvis; and sensory organ. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in alcohol dependence; hypertension; and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2).
- Alternative Names
- NE-T, NET, Slc6a5
- Gene ID
- 20538
- UniProt ID
- Q8R2I2
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Datasheet
MSDS
COA
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See other products for "SLC6A2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3108z | Mouse Anti-SLC6A2 Recombinant Antibody (clone 43B9) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| VS-0223-WK49 | Rabbit Anti-SLC6A2 Recombinant Antibody (VS-0223-WK49) | IHC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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