Recombinant Anti-SLC6A4 Vesicular Antibody, EV Displayed (VS-0425-YC422)
CAT#: VS-0425-YC422
The Recombinant Anti-SLC6A4 Vesicular Antibody, EV Displayed (VS-0425-YC422) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SLC6A4-expressed cells or tissues. The SLC6A4 is a serotonin transporter, crucial for neurotransmitter recycling, with involvement in conditions like SIDS and depression.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74728/1528_G11_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuropil Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54723/167658_B_8_5.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54723/167658_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54723/167658_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54723/167658_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (BEWO, CACO-2, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000108576-SLC6A4
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SLC6A4
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Solute carrier family 6 member 4
- Biological Process
- Antiport, Neurotransmitter transport, Transport
- Cellular Localization
- Golgi apparatus, Vesicles
- Introduction
- This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
- Alternative Names
- 5-HTT, HTT, OCD1, SERT1
- Gene ID
- 6532
- UniProt ID
- P31645
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "SLC6A4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2285z | Mouse Anti-SLC6A4 Recombinant Antibody (clone 39A8) | WB | Mouse IgM |
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| PABJ-0101 | Mouse Anti-SLC6A4 Recombinant Antibody (clone 15B8) | ELISA | Mouse IgG |
| ZG-0565U | Rabbit Anti-SLC6A4 Recombinant Antibody (clone 9G3) | ELISA, WB, IHC | Rabbit IgG |
| VS-0223-WK61 | Rabbit Anti-SLC6A4 Recombinant Antibody (VS-0223-WK61) | IHC, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3310 | Hi-Affi™ Recombinant Rabbit Anti-SLC6A4 Monoclonal Antibody (DS3310AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-460 | Mouse Anti-SLC6A4 Recombinant Antibody (clone 8B6); Fab Fragment | ELISA, FC | Mouse Fab |
| PABJ-0101-F(E) | Mouse Anti-SLC6A4 Recombinant Antibody (clone 15B8); Fab fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-460 | Mouse Anti-SLC6A4 Recombinant Antibody (clone 8B6); scFv Fragment | ELISA, FC | Mouse scFv |
| PABJ-0101-S(P) | Mouse Anti-SLC6A4 Recombinant Antibody (clone 15B8); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6693 | Anti-SLC6A4 Immunohistochemistry Kit | IHC |
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