Recombinant Mouse Anti-SMC1A Antibody (VS4-CJ121)
CAT#: VS4-CJ121
This mouse anti-SMC1A antibody is a product that recognizes human, porcine, mouse, rat SMC1A. The immunogen of this antibody is recombinant fragment, corresponding to amino acids 2aa-351aa of human SMC1A (N-terminus). The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunohistochemistry (1:50-1:500).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25404/if_selected.jpg
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Specifications
- Immunogen
- Recombinant fragment, corresponding to amino acids 2aa-351aa of human SMC1A (N-terminus).
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human, Porcine, Mouse, Rat SMC1A
- Species Reactivity
- Human, Porcine, Mouse, Rat
- Applications
- ELISA, WB, IHC, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.
- Preservative
- 0.2% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunohistochemistry (1:50-1:500).
Target
- Alternative Names
- CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
- Gene ID
- 8243
- UniProt ID
- Q14683
- Long Name
- Structural maintenance of chromosomes 1A
- Sequence Similarities
- Belongs to the SMC family. SMC1 subfamily.
- Cellular Localization
- Nucleus, Centromere, Chromosome, Kinetochore
- Post Translation Modifications
- Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.
Phosphorylated by ATM upon ionizing radiation in a NBS1-dependent manner. Phosphorylated by ATR upon DNA methylation in a MSH2/MSH6-dependent manner. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation.
- Protein Refseq
- NP_006297.2
- Function
- Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SMC1A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3335 | Hi-Affi™ Recombinant Rabbit Anti-SMC1A Monoclonal Antibody (DS3335AB) | WB, IHC, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2382-CN | Recombinant Rabbit Anti-SMC1A (phosphorylated Ser957) Monoclonal Antibody (CBACN-667) | WB, IHC, IF | Rabbit IgG |
| VS3-QX1032 | Mouse Anti-SMC1A Recombinant Antibody (clone 8E6-A4-F3) | WB, IHC, FC | Mouse IgG1 |
| VS3-XY1438 | Mouse Anti-SMC1A Recombinant Antibody (clone 5D5B8) | ELISA, WB, FC, IHC, ICC | Mouse IgG1 |
| VS3-WK967 | Rabbit Anti-SMC1A Recombinant Antibody (VS3-WK967) | WB, ICC, IF, IHC | Rabbit IgG |
| VS3-WK2134 | Rabbit Anti-SMC1A (pS957) Recombinant Antibody (clone R09-9X2) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2119 | Anti-SMC1A Immunohistochemistry Kit | IHC | |
| VS-0525-XY6741 | Anti-Mouse SMC1A Immunohistochemistry Kit | IHC | |
| VS-0525-XY6740 | Anti-Human SMC1A Immunohistochemistry Kit | IHC |
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