Recombinant Rabbit Anti-SOX10 Antibody (clone R09-7D8)
CAT#: VS3-FY1374
This product is a recombinant rabbit antibody that recognizes SOX10. This antibody has been reported for use in Western Blot. The clone R09-7D8 is specific for human, rat SOX10. The antigen is human sox10 synthetic peptide.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68898/1371_E3_1_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3171/9957_B_9_5.jpg
Normal Tissue
Figure 3 Salivary gland
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3171/9957_B_1_1.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3171/9957_A_8_3.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (SK-MEL-30, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000100146-SOX10
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WB
Figure 1. Recombinant Rabbit Anti-SOX10 Antibody (clone R09-7D8) in WB.
Western Blot analysis of SOX10 in rat brain, C6, HeLa lysates using SOX10 Antibody.
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Specifications
- Immunogen
- Human SOX10 synthetic peptide.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Rat SOX10
- Species Reactivity
- Human, Rat
- Clone
- R09-7D8
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- Calculated MW: 50 kDa; Observed MW: 62 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- SRY-Box 10; Dominant Megacolon, Mouse, Human Homolog Of; SRY (Sex Determining Region Y)-Box 10; SRY-Related HMG-Box Gene 10; Transcription Factor SOX-10; SRY Box 10
- Gene ID
- 6663
- UniProt ID
- P56693
- Cellular Localization
- Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus
- Protein Refseq
- NP_008872.1
- Function
- Transcription factor that plays a central role in developing and mature glia (By similarity).
Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity).
Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity).
Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087).
Transcriptional activator of MBP, via binding to the gene promoter (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "SOX10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3374 | Hi-Affi™ Recombinant Rabbit Anti-SOX10 Monoclonal Antibody (DS3374AB) | WB, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-083CN | Mouse Anti-SOX10 Recombinant Antibody (NS-083CN) | WB, ELISA, ICC, IHC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-083CN-F(E) | Mouse Anti-SOX10 Recombinant Antibody; Fab Fragment (NS-083CN-F(E)) | WB, ELISA, ICC, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-083CN-S(P) | Mouse Anti-SOX10 Recombinant Antibody; scFv Fragment (NS-083CN-S(P)) | WB, ELISA, ICC, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1422-CN | Recombinant Mouse Anti-SOX10 Monoclonal Antibody (1-11) | WB, IHC | Mouse IgG1 |
| MRO-1423-CN | Recombinant Rabbit Anti-SOX10 Monoclonal Antibody (CBACN-520) | WB, IF | Rabbit IgG |
| MRO-1424-CN | Recombinant Rabbit Anti-SOX10 Monoclonal Antibody (CBACN-521) | WB, IF, IHC | Rabbit IgG |
| ZG-0576U | Rabbit Anti-SOX10 Recombinant Antibody (clone 8E1) | ELISA, WB, IHC, IF | Rabbit IgG |
| VS3-CJ1054 | Rabbit Anti-SOX10 Recombinant Antibody (VS3-CJ1054) | WB, ICC, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2148 | Anti-SOX10 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6815 | Anti-Mouse SOX10 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6814 | Anti-Human SOX10 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6816 | Anti-Rat SOX10 Immunohistochemistry Kit | IHC |
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