Recombinant Rabbit Anti-SOX10 Antibody (clone R09-7D8) (CAT#: VS3-FY1374)

• Immunogen
• Human SOX10 synthetic peptide.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Rat SOX10

• Species Reactivity
• Human, Rat

• Clone
• R09-7D8

• Applications
• Western Blot

• Conjugate
• Unconjugated

• MW
• Calculated MW: 50 kDa; Observed MW: 62 kDa

• Purification
• Affinity Purified

• Purity
• >95% as determined by SDS-PAGE

• Buffer
• 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• SRY-Box 10; Dominant Megacolon, Mouse, Human Homolog Of; SRY (Sex Determining Region Y)-Box 10; SRY-Related HMG-Box Gene 10; Transcription Factor SOX-10; SRY Box 10

• Gene ID
• 6663

• UniProt ID
• P56693

• Cellular Localization
• Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

• Protein Refseq
• NP_008872.1

• Function
• Transcription factor that plays a central role in developing and mature glia (By similarity).
  Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity).
  Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity).
  Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087).
  Transcriptional activator of MBP, via binding to the gene promoter (By similarity).

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-060CQ
• Llama Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Select a product category from the dropdown menu below to view related products.