Recombinant Anti-TCIRG1 Vesicular Antibody, EV Displayed (VS-0425-YC578)

CAT#: VS-0425-YC578

The Recombinant Anti-TCIRG1 Vesicular Antibody, EV Displayed (VS-0425-YC578) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TCIRG1-expressed cells or tissues. TCIRG1 is a subunit of the vacuolar H±ATPase (V-ATPase) complex, vital for pH regulation in cells. It aids in intracellular processes like protein sorting and receptor-mediated endocytosis, with mutations linked to infantile malignant osteopetrosis.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 IHC staining of human bone marrow Figure 3 Cerebral cortex Figure 4 Lung Figure 5 Colon Figure 6 Kidney Figure 7 Testis Figure 8 RNA cell line category: Cell line enhanced (HMC-1, RPMI-8226)

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • TCIRG1
  • Host Animal
  • Human
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • z domain
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Binding Affinity
  • Kd = 0.85 µg/mL
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
  • Biological Process
  • Hydrogen ion transport, Ion transport, Transport
  • Cellular Localization
  • Mitochondria
  • Introduction
  • This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]
  • Alternative Names
  • a3, Atp6i, ATP6N1C, ATP6V0A3, OC-116, OC116, TIRC7
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VS-0525-XY7142 Anti-TCIRG1 Immunohistochemistry Kit IHC
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