Recombinant Anti-TGFA Vesicular Antibody, EV Displayed (VS-0425-YC553)
CAT#: VS-0425-YC553
The Recombinant Anti-TGFA Vesicular Antibody, EV Displayed (VS-0425-YC553) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TGFA-expressed cells or tissues. TGFA is a growth factor involved in cell proliferation through EGFR activation. It may act as a transmembrane or soluble ligand, with associations to cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/476_C8_2_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/94418_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/94418_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/94418_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/94418_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/94418_A_4_6.jpg
Normal Tissue
Figure 9 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42297/94418_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HBEC3-KT, OE19, RPTEC TERT1, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163235-TGFA
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TGFA
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Transforming growth factor alpha
- Molecular Function
- Growth factor, Mitogen
- Cellular Localization
- Vesicles
- Introduction
- This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- Gene ID
- 7039
- UniProt ID
- P01135
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CITATIONS
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Related Diseases
Non-small Cell Lung Cancer
Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "TGFA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-122 | Mouse Anti-TGFA Recombinant Antibody (clone tAb2) | WB, FuncS | Mouse IgG |
| MOB-2017CT | Recombinant Mouse anti-Human TGFA Monoclonal antibody (Q/U2) | ELISA, ICC, IHC-Fr, IHC-P | |
| HPAB-0544-CN | Mouse Anti-TGFA Recombinant Antibody (HPAB-0544-CN) | WB, ELISA, FC, IHC, IP, Neut | Mouse IgG1, κ |
| HPAB-0545-CN | Mouse Anti-TGFA Recombinant Antibody (HPAB-0545-CN) | WB, ELISA, FC, IHC, IP, Neut | Mouse IgG1, κ |
| PABC-538 | Human Anti-TGFA Recombinant Antibody (PABC-538) | ELISA, FC, Neut, WB | Humanized IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-122 | Mouse Anti-TGFA Recombinant Antibody (clone tAb2); Fab Fragment | WB, FuncS | Mouse Fab |
| HPAB-0544-CN-F(E) | Mouse Anti-TGFA Recombinant Antibody; Fab Fragment (HPAB-0544-CN-F(E)) | WB, ELISA, FC, IHC, IP, Neut | Mouse Fab |
| HPAB-0545-CN-F(E) | Mouse Anti-TGFA Recombinant Antibody; Fab Fragment (HPAB-0545-CN-F(E)) | WB, ELISA, FC, IHC, IP, Neut | Mouse Fab |
| HPAB-0546-CN-F(E) | Mouse Anti-TGFA Recombinant Antibody; Fab Fragment (HPAB-0546-CN-F(E)) | WB, ELISA, FC, IHC, IP, Neut | Mouse Fab |
| PFBC-538 | Human Anti-TGFA Recombinant Antibody Fab Fragment (PFBC-538) | ELISA, FC, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-122 | Mouse Anti-TGFA Recombinant Antibody (clone tAb2); scFv Fragment | WB, FuncS | Mouse scFv |
| HPAB-0544-CN-S(P) | Mouse Anti-TGFA Recombinant Antibody; scFv Fragment (HPAB-0544-CN-S(P)) | WB, ELISA, FC, IHC, IP, Neut | Mouse scFv |
| HPAB-0545-CN-S(P) | Mouse Anti-TGFA Recombinant Antibody; scFv Fragment (HPAB-0545-CN-S(P)) | WB, ELISA, FC, IHC, IP, Neut | Mouse scFv |
| HPAB-0546-CN-S(P) | Mouse Anti-TGFA Recombinant Antibody; scFv Fragment (HPAB-0546-CN-S(P)) | WB, ELISA, FC, IHC, IP, Neut | Mouse scFv |
| PSBC-538 | Human Anti-TGFA Recombinant Antibody scFv Fragment (PSBC-538) | ELISA, FC, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0533CL | Mouse Anti-TGFA Recombinant Antibody (TAB-0533CL) | ELISA, Inhib | Mouse IgG |
| TAB-0533CL-S(P) | Mouse Anti-TGFA Recombinant Antibody; scFv Fragment (TAB-0533CL-S(P)) | ELISA, Inhib | Mouse scFv |
| TAB-0533CL-F(E) | Mouse Anti-TGFA Recombinant Antibody; Fab Fragment (TAB-0533CL-F(E)) | ELISA, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY251 | AbPlus™ Anti-TGFA Magnetic Beads (VS-0424-XY251) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7205 | Anti-TGFA Immunohistochemistry Kit | IHC | |
| VS-0525-XY7206 | Anti-Mouse TGFA Immunohistochemistry Kit | IHC | |
| VS-0525-XY7207 | Anti-Human TGFA Immunohistochemistry Kit | IHC |
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