Recombinant Anti-TIE1 Vesicular Antibody, EV Displayed (VS-0425-YC581) (CAT#: VS-0425-YC581)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• TIE1

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Mouse

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Tyrosine kinase with immunoglobulin like and EGF like domains 1

• Biological Process
• Angiogenesis

• Molecular Function
• Kinase, Receptor, Transferase, Tyrosine-protein kinase

• Introduction
• This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

• Alternative Names
• JTK14, TIE

• Gene ID
• 7075

• UniProt ID
• P35590

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