Recombinant Anti-TIE1 Vesicular Antibody, EV Displayed (VS-0425-YC581)
CAT#: VS-0425-YC581
The Recombinant Anti-TIE1 Vesicular Antibody, EV Displayed (VS-0425-YC581) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TIE1-expressed cells or tissues. TIE1 is a tyrosine kinase family member that regulates angiogenesis by inhibiting angiopoietin 1 signaling through the Tie2 receptor. Ectodomain cleavage relieves Tie2 inhibition.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (EFO-21, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000066056-TIE1
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TIE1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Tyrosine kinase with immunoglobulin like and EGF like domains 1
- Biological Process
- Angiogenesis
- Molecular Function
- Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Introduction
- This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
- Alternative Names
- JTK14, TIE
- Gene ID
- 7075
- UniProt ID
- P35590
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "TIE1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-608CL | Human Anti-TIE1 Recombinant Antibody (TAB-608CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0314CQ-F(E) | Human Anti-TIE1 Recombinant Antibody; Fab Fragment (HPAB-0314CQ-F(E)) | ELISA, FC, WB, IHC, IF, Agonist | Human Fab |
| HPAB-0315CQ-F(E) | Human Anti-TIE1 Recombinant Antibody; Fab Fragment (HPAB-0315CQ-F(E)) | ELISA, FC, WB, IHC, IF, Block | Human Fab |
| HPAB-0316CQ-F(E) | Human Anti-TIE1 Recombinant Antibody; Fab Fragment (HPAB-0316CQ-F(E)) | ELISA, FC, WB, IHC, IF, Block | Human Fab |
| HPAB-0317CQ-F(E) | Human Anti-TIE1 Recombinant Antibody; Fab Fragment (HPAB-0317CQ-F(E)) | ELISA, FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0314CQ-S(P) | Human Anti-TIE1 Recombinant Antibody; scFv Fragment (HPAB-0314CQ-S(P)) | ELISA, FC, WB, IHC, IF, Agonist | Human scFv |
| HPAB-0315CQ-S(P) | Human Anti-TIE1 Recombinant Antibody; scFv Fragment (HPAB-0315CQ-S(P)) | ELISA, FC, WB, IHC, IF, Block | Human scFv |
| HPAB-0316CQ-S(P) | Human Anti-TIE1 Recombinant Antibody; scFv Fragment (HPAB-0316CQ-S(P)) | ELISA, FC, WB, IHC, IF, Block | Human scFv |
| HPAB-0317CQ-S(P) | Human Anti-TIE1 Recombinant Antibody; scFv Fragment (HPAB-0317CQ-S(P)) | ELISA, FC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY1523 | Mouse Anti-TIE1 Recombinant Antibody (clone 2B12) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-XY1524 | Mouse Anti-TIE1 Recombinant Antibody (clone 6E6) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-XY1525 | Mouse Anti-TIE1 Recombinant Antibody (clone 8D12B10) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-XY1526 | Mouse Anti-TIE1 Recombinant Antibody (clone 8D12D2) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-WK1255 | Mouse Anti-TIE1 Recombinant Antibody (VS3-WK1255) | ELISA, WB | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY15 | Mouse Anti-TIE1 scFv-Fc Chimera (VS-0325-FY15) | ELISA, FC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7254 | Anti-TIE1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7255 | Anti-Human TIE1 Immunohistochemistry Kit | IHC |
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