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    Recombinant Human Anti-TMEFF2 Antibody (clone 6G6) (CAT#: VS4-CJ136)

    This human anti-TMEFF2 antibody (clone 6G6) is a product that recognizes human TMEFF2. The immunogen of this antibody is recombinant human TMEFF2 protein. The mAb has been tested for use in ELISA.

    Specific Inquiry
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    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Cerebral cortex
    Figure 1 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_B_7_5.jpg
    Figure 2 Colon
    Figure 2 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_9_3.jpg
    Figure 3 Liver
    Figure 3 Liver
    (Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_9_4.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_7_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_5_6.jpg
    Figure 6 Prostate
    Figure 6 Prostate
    (Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_2_5.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_7_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Group enriched (AF22, LHCN-M2)
    Figure 8 RNA cell line category: Group enriched (AF22, LHCN-M2)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000144339-TMEFF2

    Specifications

    • Immunogen
    • Recombinant Human TMEFF2 protein
    • Host Species
    • Human
    • Type
    • Human IgG4 (S228P)
    • Specificity
    • Human TMEFF2
    • Species Reactivity
    • Human
    • Clone
    • 6G6
    • Applications
    • ELISA
    • Conjugate
    • Unconjugated

    Product Property

    • Purification
    • Affinity chromatography
    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Buffer
    • 50% Glycerol, 0.01M PBS, pH 7.4.
    • Preservative
    • 0.03% Proclin 300
    • Storage
    • Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

    Applications

    • Application Notes
    • This antibody has been tested for use in ELISA.

    Target

    • Alternative Names
    • TR; HPP1; TPEF; TR-2; TENB2; CT120.2
    • Long Name
    • Transmembrane protein with EGF like and two follistatin like domains 2
    • Sequence Similarities
    • Belongs to the tomoregulin family.
    • Cellular Localization
    • Membrane, Secreted
    • Post Translation Modifications
    • O-glycosylated; contains chondroitin sulfate glycosaminoglycans.
      A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
    • Function
    • May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Recommended Dilution Buffer

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    CAT Product Name Application Type
    MOB-3543z Mouse Anti-TMEFF2 Recombinant Antibody (MOB-3543z) ELISA, IHC, WB, IF Mouse IgG
    HPAB-0022-LS Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19) ELISA Humanized IgG

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