Recombinant Anti-TNFSF14 Vesicular Antibody, EV Displayed (VS-0425-YC484)
CAT#: VS-0425-YC484
The Recombinant Anti-TNFSF14 Vesicular Antibody, EV Displayed (VS-0425-YC484) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TNFSF14-expressed cells or tissues. TNFSF14 is a TNF ligand that interacts with TNFRSF14 and may facilitate lymphoid cell activation and herpesvirus infection inhibition. This protein promotes T cell proliferation and tumor cell apoptosis. Various transcript variants exist for TNFSF14.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/2061_E6_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in umbrella cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HDLM-2, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125735-TNFSF14
❮
❯
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TNFSF14
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- TNF superfamily member 14
- Molecular Function
- Cytokine
- Cellular Localization
- Vesicles
- Introduction
- The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
- Alternative Names
- CD258, HVEM-L, LIGHT, LTg
- Gene ID
- 8740
- UniProt ID
- O43557
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MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3612z | Mouse Anti-TNFSF14 Recombinant Antibody (clone 19G4) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| MOB-1093CT | Recombinant Mouse anti-Human TNFSF14 Monoclonal antibody (EML2020) | IHC-P, WB | |
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| HPAB-J0293-YC | Mouse Anti-TNFSF14 Recombinant Antibody (clone m10D11) | Inhib, Block | Mouse IgG |
| VS3-FY2770 | Mouse Anti-TNFSF14 Recombinant Antibody (VS3-FY2770) | WB, IHC, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-159CQ | Anti-Human TNFSF14 Recombinant Antibody (TR01G03) | ELISA, FC, WB | Human antibody |
| TAB-159CQ-S(P) | Anti-Human TNFSF14 Recombinant Antibody scFv Fragment (TR01G03) | ELISA, FC, WB | Human antibody |
| TAB-159CQ-F(E) | Anti-Human TNFSF14 Recombinant Antibody Fab Fragment (TR01G03) | ELISA, FC, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0404-YC-F(E) | Human Anti-TNFSF14 Recombinant Antibody; Fab Fragment (HPAB-N0404-YC-F(E)) | ELISA, FC, Inhib | Human Fab |
| HPAB-0106LY-F(E) | Human Anti-TNFSF14 Recombinant Antibody; Fab Fragment (HPAB-0106LY-F(E)) | ELISA, RIA, Block, FC | Human Fab |
| HPAB-J0293-YC-F(E) | Mouse Anti-TNFSF14 Recombinant Antibody (clone m10D11); Fab Fragment | ELISA, FC, Inhib | Mouse Fab |
| HPAB-J0294-YC-F(E) | Mouse Anti-TNFSF14 Recombinant Antibody (clone m5E10); Fab Fragment | ELISA, FC, Inhib | Mouse Fab |
| HPAB-J0295-YC-F(E) | Mouse Anti-TNFSF14 Recombinant Antibody (clone m13C7); Fab Fragment | ELISA, FC, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0847-CN-S(P) | Human Anti-TNFSF14 Recombinant Antibody (clone h5E10); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0848-CN-S(P) | Human Anti-TNFSF14 Recombinant Antibody (clone h10D11); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0849-CN-S(P) | Human Anti-TNFSF14 Recombinant Antibody (clone h14G8); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0850-CN-S(P) | Human Anti-TNFSF14 Recombinant Antibody (clone h18B1); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0106LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0106LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1170 | CytoStream™ Rabbit Anti-TNFSF14 Recombinant Antibody (VS13-YC1170) | FC, ELISA | Rabbit IgG |
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