Recombinant Anti-TREM1 Vesicular Antibody, EV Displayed (VS-0425-YC229)
CAT#: VS-0425-YC229
The Recombinant Anti-TREM1 Vesicular Antibody, EV Displayed (VS-0425-YC229) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TREM1-expressed cells or tissues. The TREM1 is a receptor amplifying inflammatory responses in myeloid cells, triggering pro-inflammatory cytokines.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53612/1743_C3_18_cr57fe217b31caf_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5563/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line SuSa
Immunofluorescent staining of human cell line SuSa shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53612/1968_F4_2_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5563/15822_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5563/15822_A_7_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5563/15822_A_9_4.jpg
Normal Tissue
Figure 7 Urinary bladder
Urothelial cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5563/15822_A_6_5.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (SuSa, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000124731-TREM1
❮
❯
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TREM1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Triggering receptor expressed on myeloid cells 1
- Biological Process
- Adaptive immunity, Immunity, Innate immunity
- Molecular Function
- Receptor
- Cellular Localization
- Golgi apparatus
- Introduction
- This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
- Alternative Names
- CD354, TREM-1
- Gene ID
- 54210
- UniProt ID
- Q9NP99
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Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2466-sdAb | Recombinant Anti-Human TREM1 VHH Single Domain Antibody | ICC, FC, WB, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-167CQ | Human Anti-TREM1 Recombinant Antibody (TAB-167CQ) | ELISA, FC, WB, Block | Humanized antibody |
| TAB-167CQ-S(P) | Human Anti-TREM1 Recombinant Antibody; scFv Fragment (TAB-167CQ-S(P)) | ELISA, FC, WB, Block | Human scFv |
| TAB-167CQ-F(E) | Human Anti-TREM1 Recombinant Antibody; Fab Fragment (TAB-167CQ-F(E)) | ELISA, FC, WB, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0682-YC | Human Anti-TREM1 Recombinant Antibody (HPAB-M0682-YC) | ELISA, FuncS | Human IgG1 |
| HPAB-M0683-YC | Human Anti-TREM1 Recombinant Antibody (HPAB-M0683-YC) | ELISA, FuncS | Human IgG1 |
| HPAB-M0684-YC | Human Anti-TREM1 Recombinant Antibody (HPAB-M0684-YC) | ELISA, FuncS | Human IgG1 |
| HPAB-0579-FY | Human Anti-TREM1 Recombinant Antibody (clone mAb 0333) | Inhib | Humanized IgG |
| VS11-QX141 | Mouse Anti-TREM1 Recombinant Antibody (clone 14F69) | ELISA, FC, Block | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0682-YC-S(P) | Human Anti-TREM1 Recombinant Antibody; scFv Fragment (HPAB-M0682-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-M0683-YC-S(P) | Human Anti-TREM1 Recombinant Antibody; scFv Fragment (HPAB-M0683-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-M0684-YC-S(P) | Human Anti-TREM1 Recombinant Antibody; scFv Fragment (HPAB-M0684-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-M0685-YC-S(P) | Human Anti-TREM1 Recombinant Antibody; scFv Fragment (HPAB-M0685-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0579-FY-S(P) | Human Anti-TREM1 Recombinant Antibody (clone mAb 0333); scFv Fragment | Inhib | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0682-YC-F(E) | Human Anti-TREM1 Recombinant Antibody; Fab Fragment (HPAB-M0682-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0683-YC-F(E) | Human Anti-TREM1 Recombinant Antibody; Fab Fragment (HPAB-M0683-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0689-YC-F(E) | Human Anti-TREM1 Recombinant Antibody; Fab Fragment (HPAB-M0689-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0690-YC-F(E) | Human Anti-TREM1 Recombinant Antibody; Fab Fragment (HPAB-M0690-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0691-YC-F(E) | Human Anti-TREM1 Recombinant Antibody; Fab Fragment (HPAB-M0691-YC-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY56 | Mouse Anti-TREM1 Agonistic Antibody (VS-0724-XY56) | FC, Agonistic assays Activity, CyTOF® | Mouse IgG1 |
| VS-0724-XY57 | Rat Anti-Trem1 Agonistic Antibody (VS-0724-XY57) | WB, FC, Agonistic assays, CyTOF®, ICC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY513 | Mouse Anti-NHP TREM1 Recombinant Antibody (clone 6B12D1) | WB, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY228 | CytoStream™ Rat Anti-TREM1 Recombinant Antibody (VS-0225-XY228) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7505 | Anti-Mouse TREM1 Immunohistochemistry Kit | IHC |
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