Recombinant Anti-TREM2 Vesicular Antibody, EV Displayed (VS-0425-YC228)
CAT#: VS-0425-YC228
The Recombinant Anti-TREM2 Vesicular Antibody, EV Displayed (VS-0425-YC228) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TREM2-expressed cells or tissues. The TREM2 is a membrane protein forming a receptor signaling complex, involved in immune response and inflammation. Defects cause PLOSL.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human gallbladder
Immunohistochemical staining of human gallbladder shows strong membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_6_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_B_8_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (hTCEpi, THP-1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000095970-TREM2
❮
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TREM2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Triggering receptor expressed on myeloid cells 2
- Molecular Function
- Receptor
- Cellular Localization
- Vesicles
- Introduction
- This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
- Alternative Names
- TREM-2, Trem2a, Trem2b, Trem2c
- Gene ID
- 54209
- UniProt ID
- Q9NZC2
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Datasheet
MSDS
COA
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See other products for "TREM2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-168CQ | Human Anti-TREM2 Recombinant Antibody (TAB-168CQ) | ELISA, FC, WB, FuncS | Human IgG |
| TAB-169CQ | Human Anti-TREM2 Recombinant Antibody (TAB-169CQ) | ELISA, FC, WB, FuncS | Human IgG |
| TAB-168CQ-S(P) | Human Anti-TREM2 Recombinant Antibody; scFv Fragment (TAB-168CQ-S(P)) | ELISA, FC, WB, FuncS | Human scFv |
| TAB-168CQ-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (TAB-168CQ-F(E)) | ELISA, FC, WB, FuncS | Human Fab |
| TAB-169CQ-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (TAB-169CQ-F(E)) | ELISA, FC, WB, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0152-CN-S(P) | Human Anti-TREM2 Recombinant Antibody (clone Pil.02.002); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0153-CN-S(P) | Human Anti-TREM2 Recombinant Antibody (clone Pil.02.005); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0154-CN-S(P) | Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0154-CN-S(P)) | WB, ELISA, FC, IHC, IF, IP | Mouse scFv |
| HPAB-0155-CN-S(P) | Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0155-CN-S(P)) | WB, ELISA, FC, IHC, IF, IP | Mouse scFv |
| HPAB-0156-CN-S(P) | Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0156-CN-S(P)) | WB, ELISA, FC, IHC, IF, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-3341LY | Human Anti-TREM2 Recombinant Antibody (HPAB-3341LY) | FC, WB, IP, ELISA, IHC | Humanized IgG |
| HPAB-3342LY | Human Anti-TREM2 Recombinant Antibody (HPAB-3342LY) | FC, WB, IP, ELISA, IHC | Humanized IgG |
| HPAB-3343LY | Human Anti-TREM2 Recombinant Antibody (HPAB-3343LY) | FC, WB, IP, ELISA, IHC | Humanized IgG |
| HPAB-3344LY | Human Anti-TREM2 Recombinant Antibody (HPAB-3344LY) | FC, WB, IP, ELISA, IHC | Humanized IgG |
| HPAB-3345LY | Human Anti-TREM2 Recombinant Antibody (HPAB-3345LY) | FC, WB, IP, ELISA, IHC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-3341LY-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-3341LY-F(E)) | FC, WB, IP, ELISA, IHC | Humanized Fab |
| HPAB-3342LY-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-3342LY-F(E)) | FC, WB, IP, ELISA, IHC | Humanized Fab |
| HPAB-3343LY-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-3343LY-F(E)) | FC, WB, IP, ELISA, IHC | Humanized Fab |
| HPAB-3344LY-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-3344LY-F(E)) | FC, WB, IP, ELISA, IHC | Humanized Fab |
| HPAB-3345LY-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-3345LY-F(E)) | FC, WB, IP, ELISA, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY58 | Mouse Anti-TREM2 Agonistic Antibody (clone al002c) | Agonistic assays, DB, ICC, IP, SPR, IF | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY262 | AbPlus™ Anti-TREM2 Magnetic Beads (VS-0424-XY262) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2348 | Anti-TREM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7507 | Anti-Rat TREM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7508 | Anti-Mouse TREM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7506 | Anti-Human TREM2 Immunohistochemistry Kit | IHC |
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