Recombinant Mouse Anti-TTR Antibody (VS4-CJ145)

Name: Recombinant Mouse Anti-TTR Antibody (VS4-CJ145)
SKU: VS4-CJ145
Rating: 5 (1 reviews)

CAT#: VS4-CJ145

This mouse anti-TTR antibody is a product that recognizes human TTR. The immunogen of this antibody is a recombinant protein corresponding to TTR. The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunohistochemistry (1:50-1:500).

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line CACO-2

Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/1030_B12_3_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human hippocampus

Immunohistochemical staining of human hippocampus shows plasma positivity in blood vessels.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/ih_additional_tissue/2550/1625_959_400x400.jpg

Subcellular Location and Protein Expression Figure 3 IHC staining of human liver

Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 4 IHC staining of human pancreas

Immunohistochemical staining of human pancreas shows selective positivity in islets of Langerhans.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62567/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 5 IHC staining of human kidney

Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/ihc_selected.jpg

Normal Tissue Figure 6 Liver

Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/6846_A_9_4.jpg

Normal Tissue Figure 7 Pancreas

Pancreatic endocrine cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/141382_A_3_3.jpg

Normal Tissue Figure 8 Kidney

Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/153523_A_7_5.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (CACO-2, EFO-21, Hep G2, U-2 OS)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118271-TTR

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Specifications

Immunogen
Recombinant Protein

Host Species
Mouse

Type
Mouse IgG

Specificity
Human TTR

Species Reactivity
Human

Applications
ELISA, WB, IHC

Conjugate
Unconjugated

Product Property

Purification
Immunogen affinity chromatography

Purity
>95% as determined by SDS-PAGE

Format
Liquid

Buffer
50% Glycerol, PBS, pH 7.4.

Preservative
0.02% Sodium Azide

Storage
Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

Applications

Application Notes
This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunohistochemistry (1:50-1:500).

Target

Alternative Names
ATTR; CTS; CTS1; HEL111; HsT2651; PALB; TBPA; TTN

Gene ID
7276

UniProt ID
P02766

Long Name
Transthyretin

Sequence Similarities
Belongs to the transthyretin family.

Cellular Localization
Amyloid, Cytoplasm, Secreted

Post Translation Modifications
Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.

Protein Refseq
NP_000362.1

Function
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS4-CJ145.pdf

MSDS

MSDS - VS4-CJ145.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Isotype Control

CAT
Product Name

Secondary Antibody

CAT
Product Name

Recommended Dilution Buffer

CAT
Product Name

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