Recombinant Rabbit Anti-TUBB3 Detection Antibody (clone R17-2B-6) (CAT#: VS3-WK1809)

• Immunogen
• Recombinant human TUBB3 protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human TUBB3

• Species Reactivity
• Human

• Clone
• R17-2B-6

• Applications
• ELISA

• Conjugate
• Unconjugated

• Clonality
• Monoclonal

• Purification
• Protein A affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Aggregation
• < 5%

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 0.01M PBS, pH 7.2

• Storage
• Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Tubulin Beta 3 Class III; Class III Beta-Tubulin; Tubulin Beta-4 Chain; Tubulin Beta-III; Tubulin, Beta 3; TUBB4; Fibrosis Of Extraocular Muscles, Congenital, 3; Tubulin Beta-3 Chain

• Gene ID
• 10381

• UniProt ID
• Q13509

• Long Name
• Tubulin Beta 3 Class III

• Sequence Similarities
• Belongs to the tubulin family.

• Cellular Localization
• Cell projection, Cytoplasm, Cytoskeleton, Microtubule

• Post Translation Modifications
• Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group.
  Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold

• Protein Refseq
• NP_001184110.1

• Function
• Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Capture antibody

• VS3-WK1808
• Recombinant Rabbit Anti-TUBB3 Capture Antibody (clone R19-9A-3)

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2RD-A1517-YJ
• Sheep Anti-Rabbit IgG-heavy and light chain Secondary antibody

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