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  • Recombinant Rabbit Anti-USP14 Antibody (clone 28C4)

Recombinant Rabbit Anti-USP14 Antibody (clone 28C4) (CAT#: VS4-CJ150)

This rabbit anti-USP14 antibody (clone 28C4) is a product that recognizes human USP14. The immunogen of this antibody is a synthesized peptide derived from human USP14. The mAb has been tested for use in ELISA, Western Blot (1:500-1:2000), Immunofluorescence (1:50-1:200).


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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1308/59_C4_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1308/3920_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1308/3920_A_9_3.jpg
Figure 4 Liver
Figure 4 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1308/3920_A_8_4.jpg
Figure 5 Pancreas
Figure 5 Pancreas
(Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1308/3920_A_2_3.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1308/3920_A_9_5.jpg
Figure 7 Testis
Figure 7 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1308/3920_A_5_6.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1308/3920_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101557-USP14

Specifications

  • Immunogen
  • A synthesized peptide derived from human USP14
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human USP14
  • Species Reactivity
  • Human
  • Clone
  • 28C4
  • Applications
  • ELISA, WB, IF
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Affinity chromatography
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
  • Preservative
  • 0.02% Sodium Azide
  • Storage
  • Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

Applications

  • Application Notes
  • This antibody has been tested for use in ELISA, Western Blot (1:500-1:2000), Immunofluorescence (1:50-1:200).

Target

  • Alternative Names
  • TGT; Ubp6
  • Long Name
  • Ubiquitin specific peptidase 14
  • Sequence Similarities
  • Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
  • Cellular Localization
  • Cell membrane, Cytoplasm, Membrane, Proteasome
  • Function
  • Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413).
    Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577).
    Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094).
    Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427).
    Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).
    Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593).

Recommended Products

Isotype Control

Secondary Antibody

Recommended Dilution Buffer

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "USP14"

Recombinant Antibody

CAT Product Name Application Type
MRO-1562-CN Rabbit Anti-USP14 Recombinant Antibody (clone JU30-49) WB, IF, IHC, FC Rabbit IgG
MRO-2258-CN Rabbit Anti-USP14 Polyclonal Antibody (MRO-2258-CN) WB, FC Rabbit IgG
VS3-QX1222 Mouse Anti-USP14 Recombinant Antibody (clone 889CT6.2.1) WB, FC Mouse IgG1
VS3-CJ1037 Mouse Anti-USP14 Recombinant Antibody (VS3-CJ1037) WB, FC Mouse IgG1
VS3-XY3536 Rabbit Anti-USP14 Recombinant Antibody (clone R09-8E9) WB, ICC, IF, FC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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