Recombinant Rabbit Anti-USP14 Antibody (clone 28C4) (CAT#: VS4-CJ150)

This rabbit anti-USP14 antibody (clone 28C4) is a product that recognizes human USP14. The immunogen of this antibody is a synthesized peptide derived from human USP14. The mAb has been tested for use in ELISA, Western Blot (1:500-1:2000), Immunofluorescence (1:50-1:200).

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Custom Production

We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • A synthesized peptide derived from human USP14
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human USP14
  • Species Reactivity
  • Human
  • Clone
  • 28C4
  • Applications
  • ELISA, WB, IF
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Affinity chromatography
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
  • Preservative
  • 0.02% Sodium Azide
  • Storage
  • Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

Applications

  • Application Notes
  • This antibody has been tested for use in ELISA, Western Blot (1:500-1:2000), Immunofluorescence (1:50-1:200).

Target

  • Alternative Names
  • TGT; Ubp6
  • Long Name
  • Ubiquitin specific peptidase 14
  • Sequence Similarities
  • Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
  • Cellular Localization
  • Cell membrane, Cytoplasm, Membrane, Proteasome
  • Function
  • Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413).
    Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577).
    Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094).
    Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427).
    Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).
    Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593).

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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