At Creative Biolabs, antibody-coupled liposomes targeting the spleen are nanoscale drug carriers made from biocompatible materials, specifically designed to deliver targeted antibodies to spleen tissue. Through specific antibody modifications, these liposomes can accurately identify and bind to characteristic cells in the spleen, ensuring that the antibodies effectively target the intended sites.

Introduction

The spleen plays a crucial role in the immune response, and by targeting it, we can more effectively direct antibody drugs to specific immune cells. By creating a liposome-based antibody-targeting delivery system, Creative Biolabs can assist clients in effectively minimizing the impact of antibodies on non-target tissues, thereby reducing side effects. Our products combine the strengths of both liposomes and antibodies, providing an opportunity to develop innovative immunotherapeutic strategies, particularly in areas such as cancer and infectious diseases.

Currently, our design, construction, and production services for spleen-targeted liposome antibody therapies integrate top drug delivery technologies with advanced immunology. By conjugating antibodies into liposomes, we enhance their stability, extend their half-life, and maintain their biological activity, thereby improving the effectiveness of the immune response. Meanwhile, our self-developed antibody-liposome products can help reduce systemic side effects, particularly in the application of antibody drugs, minimizing damage to normal tissues.

Fig.1 A Liposome Diagram.^1,3

Services

In recent years, innovative technologies for targeted drug delivery systems have been emerging, especially in the integration of antibody engineering and liposomes, capturing the attention of an increasing number of researchers and pharmaceutical companies. In this field, Creative Biolabs is dedicated to providing comprehensive technical support and preclinical CRO services for spleen-targeted liposomes loaded with antibodies, aiming to help clients accelerate their R&D processes and achieve greater efficacy and safety.

In the preparation of liposomes in our labs, the first step involves selecting appropriate lipid materials, typically phospholipids such as lecithin and hydrogenated soybean phosphatidylcholine, along with their derivatives. Subsequently, the desired liposomes are formed using techniques such as the thin film method, ultrasonic methods, or membrane extrusion.

Next, during the selection and modification of antibodies, it is crucial to choose target antibodies that exhibit high specificity for the spleen, such as those directed against specific cells within the spleen. Additionally, antibodies can be modified through chemical interactions or genetic engineering techniques to enhance their stability and targeting capabilities.

During the functionalization of liposomes, targeting ligands are chemically linked to the surface of the liposomes, which improves their ability to specifically target the spleen. Surface modifications, such as the use of polyethylene glycol (PEG), can help prolong the half-life of the liposomes in plasma. For antibody loading, passive loading techniques can be employed, such as solvent evaporation or ultrasonic treatment to incorporate antibodies into the liposomes. Alternatively, active loading methods can be used, where appropriate conditions encourage antibodies to spontaneously embed within the liposomes.

Upon completion of these steps, it is essential to characterize the liposomes, determining their physicochemical properties such as particle size, ζ-potential, and encapsulation efficiency. Furthermore, functional testing in vitro or in vivo models is necessary to evaluate the targeting efficiency of the liposomes and the biological activity of the antibodies. Finally, during the animal experimentation phase, pharmacokinetic studies will be conducted to assess the in vivo distribution of the liposomes, particularly their targeting abilities in the spleen. It is also important to observe the efficacy of antibody delivery via spleen targeting in treating relevant pathological conditions.

Fig.2 Kinetics Analysis of Nanoparticle Diffusion into the Spleen During the ABC Phenomenon.^2,3

Features

Creative Biolabs can provide efficient and high-quality antibody-coupled liposome research and development support for pharmaceutical and biotechnology companies, facilitating the development and launch of new therapies.

• Expert Knowledge and Experience: Creative Biolabs boasts a team of highly qualified scientists and researchers with a deep understanding and extensive practical experience in liposome preparation and antibody engineering, enabling them to effectively guide and support clients' research projects.
• Comprehensive Service Range: Creative Biolabs offers a full suite of services, from antibody discovery and liposome design to preclinical research, meeting clients' needs across various project stages.
• Cost Effectiveness: By outsourcing research activities, we help clients reduce R&D expenses and conserve internal resources, allowing them to focus on their core business.
• Flexibility and Adaptability: Creative Biolabs can customize its liposome antibody services to meet specific client requirements, adjusting project plans as needed and quickly responding to market changes.
• State-of-the-Art Technology and Facilities: Creative Biolabs invests in modern laboratory equipment and technologies to deliver high-quality data and results, enhancing research efficiency.
• Global Network Presence: Creative Biolabs has branches in multiple countries and regions, enabling it to provide worldwide services and assist clients in entering international markets.
• Data Management and Analysis: Creative Biolabs possesses advanced data management and analysis capabilities, offering clients deep insights and scientific foundations to support informed decision-making.

Creative Biolabs offers a variety of services for the development of antibody-coupled liposomes targeted to the spleen. Our services include the production of recombinant antibodies, selection and optimization of coupling agents, conjugation synthesis, and characterization analysis of the final product. We employ advanced liposome preparation technology in conjunction with biochemical engineering to ensure the stability and activity of antibodies during the delivery process. If you are interested in our targeted spleen antibody-coupled liposome services or have any questions, please feel free to contact us.

For research use only. Not intended for any clinical use.