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AAF

Anti-AAF Products
- Recombinant Anti-AAF Antibody (MOB-17)
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- Derivation: Mouse
- Type: IgG
- Application: ELISA, WB, IP, FuncS
- Recombinant Human Anti-AAF Antibody (MHH-17)
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- Derivation: Human
- Type: IgG
- Application: Neut, WB, FuncS
- Recombinant Human Anti-AAF Antibody Fab Fragment (MHH-17-F(E))
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- Derivation: Human
- Type: Fab
- Application: WB, Dot, FuncS
- Recombinant Human Anti-AAF Antibody scFv Fragment (MHH-17-S(P))
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- Derivation: Human
- Type: scFv
- Application: ELISA, IP, FuncS
- Recombinant Anti-AAF Antibody Fab Fragment (MOB-17-F(E))
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- Derivation: Mouse
- Type: Fab
- Application: IF, WB, FuncS
- Recombinant Anti-AAF Antibody scFv Fragment (MOB-17-S(P))
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- Derivation: Mouse
- Type: scFv
- Application: IF, Neut, FuncS
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For Research Use Only. Not For Clinical Use.
2-Acetylaminofluorene (AAF, 2-AAF) is a carcinogenic and mutagenic derivative of fluorene. It is used as a biochemical tool in the study of carcinogenesis. It induces tumors in a number of species in the liver, bladder and kidney. The metabolism of this compound in the body by means of biotransformation reactions is the key to its carcinogenicity. 2-AAF is a substrate for cytochrome P-450 (CYP) enzyme, which is a part of a super family found in almost all organisms. This reaction results in the formation of N-hydroxy-2-acetylaminofluorene which is a proximal carcinogen and is more potent than the parent molecule. The N-hydroxy metabolite undergoes several enzymatic and non-enzymatic rearrangements. It can be O-acetylated by cytosolic N-acetyltransferase enzyme to yield N-acetyl-N-acetoxyaminofluorene. This intermediate can spontaneously rearrange to form the arylamidonium ion and a carbonium ion which can interact directly with DNA to produce DNA adducts. In addition to esterification by acetylation, the N-hydroxy derivative can be O-sulfated by cytosolic sulfur transferase enzyme giving rise to the N-acetyl-N-sulfoxy product.