Anti-ACTA2 Recombinant Antibody Products

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Anti-ACTA2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs stands at the forefront of delivering innovative recombinant antibody solutions against ACTA2, playing a pivotal role in advancing biomedical research initiatives. By leveraging our cutting-edge technological platforms, we ensure that our products adhere to the strictest benchmarks of quality and performance. Our unwavering dedication to accelerating scientific exploration and discovery is evident in our comprehensive portfolio of recombinant solutions, each meticulously designed to provide exceptional value and reliability. In addition to our premium-grade antibodies, we take great pride in offering top-tier technical support to assist researchers at every phase of their work. With Creative Biolabs, you not only gain access to groundbreaking solutions but also secure a committed partner in your scientific journey, dedicated to fostering your research success.

ACTA2: A Key Contributor to Vascular Fibrotic and Tumor Associated Disorders

ACTA2 encodes smooth muscle alpha-actin, an essential component of the contractile apparatus in vascular smooth muscle cells. Alterations in this gene are associated with numerous pathological disorders. Mutations can weaken blood vessel structure, leading to serious conditions such as thoracic aortic aneurysms and dissections, where arterial wall integrity is compromised. Abnormal levels of ACTA2 also contribute to hypertension by affecting vascular tone and responsiveness. In fibrotic diseases, the elevated expression of this cytoskeletal protein in myofibroblasts is linked to excessive extracellular matrix buildup, causing tissue rigidity and gradual organ failure, as observed in pulmonary fibrosis and liver cirrhosis. Additionally, increased ACTA2 expression is noted in various cancers, where it may affect the tumor microenvironment and promote invasive characteristics by altering cell adhesion and movement. The protein plays a vital role in wound healing and tissue remodeling, though its chronic activation can lead to pathological fibrosis. Its involvement in maintaining vascular contractility and cellular structure underlines its significance in both structural and signaling disruptions across cardiovascular, fibrotic, and cancerous diseases. Consequently, ACTA2 is an important target for therapeutic interventions and diagnostic tools addressing disorders linked to abnormal smooth muscle or fibroblast function.

Alternative Names

Complement Actin, Alpha 2, Smooth Muscle, Aorta; Cell Growth-Inhibiting Gene 46 Protein; ACTSA; Actin, Aortic Smooth Muscle; Alpha-Cardiac Actin; Alpha-Actin-2; ACTVS

Background

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome.

Anti-ACTA2 rAb Products

Our anti-ACTA2 recombinant antibodies are designed to support your research with consistent performance and reliable results. We prioritize quality at every step—from development to validation—so you can focus on discovery without compromise. Alongside our products, we offer expert technical guidance to help troubleshoot experiments, optimize protocols, and ensure success. Whether for basic research or advanced applications, our goal is to provide tools that simplify your workflow and enhance reproducibility. Let us help you move science forward with confidence.

Creative Quality Control

At the core of our mission is a commitment to advancing biopharmaceutical research and commercialization by putting customer priorities first through dependable, premium-quality products. With a rigorous quality management system in place, we guarantee consistent product performance that aids in accelerating drug development and shortening project timelines. More than just fulfilling standards, we aim to provide solutions that improve operational efficiency, enabling researchers to make significant strides with greater speed.

Customer Reviews

Excellent

Mi**s
Mouse Anti-ACTA2 Recombinant Antibody (clone HHF35) (CAT#: ZG-1036F)

We used the Mouse Anti-ACTA2 Recombinant Antibody in ELISA assays with rat aortic smooth muscle cell lysates. The antibody delivered consistent and specific binding, with minimal nonspecific signal. It worked well with our existing ELISA setup and required no major adjustments. Results were reproducible across different runs, making it a dependable option for detecting smooth muscle markers in vascular-related studies.

11/Mar/2024

Excellent

S**la
Mouse Anti-ACTA2 Recombinant Antibody (clone 3F11-C2-G6) (CAT#: VS3-QX12)

Tested the Mouse Anti-ACTA2 in flow cytometry with primary human smooth muscle cells. It gave a clean, specific signal with minimal background, though optimal dilution needed slight tweaking. Tried it in IF with fixed fibroblasts—decent staining but required longer blocking to reduce nonspecific binding. Didn’t test WB, but for FC, it’s solid. Would use again for suspension cells but might explore other clones for tricky samples.

17/Oct/2023

Excellent

Si**a
Mouse Anti-ACTA2 Recombinant Antibody (ZG-0261F) (CAT#: ZG-0261F)

The mouse anti-ACTA2 recombinant antibody demonstrated robust performance in my ELISA experiments using human plasma samples, yielding distinct dose-response relationships. Tested WB on NIH/3T3 and HeLa cell lysates—sharp bands at ~42kDa without cross-reactivity. Tried IHC-P on human lung tissue too—specific staining in smooth muscle cells, minimal background. Required minimal optimization for dilution. Solid performance for ACTA2 detection in both cell and tissue-based assays.

16/Dec/2023

rAb Production

Over the years, we have accumulated extensive expertise in recombinant antibody development and optimization. Through our top-tier service offerings, we deliver high-quality recombinant antibody products that meet superior standards and ensure reliability within the shortest achievable timeframe. This commitment to excellence allows us to provide not just products but comprehensive solutions that align with our clients' research needs effectively.

Featured Anti-ACTA2 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-ACTA2 recombinant antibody production.

Fig.4 Gram-scale anti-ACTA2 recombinant antibody production.

rAb Modalities

At Creative Biolabs, we deliver high-quality recombinant antibodies in various formats to support your research needs. Leveraging advanced antibody engineering techniques, we also offer tailored solutions to address specific project challenges. Our goal is to provide reliable tools and customized services that help accelerate your scientific discoveries.

Fig.5 Full Length Anti-ACTA2 Recombinant Antibody Production and Modalities.

For any additional details on target ACTA2, please do not hesitate to contact us by phone or email at your convenience. Our expert team is readily available to help address any queries or experimental challenges you may encounter, ensuring you receive the necessary support to drive your research toward success. We are committed to being your reliable partner throughout the process, so feel free to reach out—no question is too small for our knowledgeable staff to assist with.