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ACTG2

Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Group enriched (Breast myoepithelial cells, Smooth muscle cells)

Immune cell specificity

Immune cell enriched (T-reg)

Cell line specificity

Cell line enhanced (BEWO, BJ hTERT+, BJ hTERT+ SV40 Large T+, HHSteC, SuSa, U-251 MG)

Interaction

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Molecular function

Muscle protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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