Metabolic proteins, Transporters
Intracellular
Cell type enhanced (Early spermatids)
Low immune cell specificity
Low cell line specificity
Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts (via GAE domain) with RABEP1 (PubMed:12773381, PubMed:14665628, PubMed:12042876). Interacts with SYNRG/gamma-synergin (PubMed:12042876). Interacts with EPS15 (By similarity). Interacts (via GAE domain) with AP1AR (via coiled-coil domain) (PubMed:15775984). Interacts with CLN3 (via dileucine motif); this interaction facilitates lysosomal targeting (PubMed:15598649). Interacts (via GAE domain) with AFTPH/aftiphilin; the interaction is required to recruit AFTPH/aftiphilin to the perinuclear region of the cell (PubMed:14665628, PubMed:15758025).
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For Research Use Only. Not For Clinical Use.