Anti-APOBEC1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs provides a unique and broad range of products and solutions for RNA biology and metabolic disease research. One of these products includes our highly specific anti-APOBEC1 recombinant antibodies. APOBEC1 is the prototypical C-to-U RNA editing enzyme and the catalytic subunit of the apolipoprotein B mRNA editing complex. Our high-quality antibodies are an essential tool for investigating the mechanism of RNA editing, lipid metabolism, and the general biology of APOBEC family proteins.

APOBEC1: The Catalytic Engine of ApoB mRNA Editing

APOBEC1 or apolipoprotein B mRNA editing enzyme catalytic polypeptide 1 is a cytidine deaminase that serves as the catalytic subunit of a multi-protein RNA-editing complex that converts a single cytidine residue in the Apolipoprotein B (ApoB) mRNA transcript. This C-to-U editing reaction, which is exclusive to the small intestine, changes the glutamine codon (CAA) into a premature stop codon (UAA), resulting in the translation of a truncated protein that is known as ApoB-48. ApoB-48 serves as a critical structural component required for chylomicron assembly and secretion during dietary fat absorption. ApoB-100, a full-length protein that is produced from the unedited transcript, is synthesized by the liver.

Alternative Names

APO1; BEDP; HEPR; CDAR1; APOBEC-1

Background

The protein encoded by this gene belongs to the cytidine deaminase family of enzymes. It has been shown to form a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme edits C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been identified for this gene.

Anti-APOBEC1 rAb Products

Our anti-APOBEC1 recombinant antibodies (rAbs) are designed to provide superior specificity and performance. Each is carefully validated to be highly specific for detection of the APOBEC1 enzyme in nuclear and cytoplasmic extracts. They are optimized for Western Blot and immunoprecipitation (including RNA-IP) applications to study the editosome complex and other proteins that associate with it. As always with Creative Biolabs' rAbs, you can expect top quality, high performance.

Table 1. Featured anti-APOBEC1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has invested in the latest production platforms to support the unique needs of RNA biology. Our anti-APOBEC1 recombinant antibodies are produced using expression and purification systems that are optimized to ensure the antibodies fully and specifically recognize the native enzyme, giving you confidence in a high specificity, highly active tool for your most critical experiments.

Featured Anti-APOBEC1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-APOBEC1 recombinant antibody production.

Fig.2 Gram-scale anti-APOBEC1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to helping you do your best science with a variety of flexible antibody modalities. Our anti-APOBEC1 recombinant antibodies are available in a range of customizable formats to meet the needs of different experiments and protocols, so that scientists around the world can study this important RNA editing enzyme.

Fig.3 Full-length anti-APOBEC1 recombinant antibody production and modalities.

Get down to the molecular details of RNA editing with Creative Biolabs' anti-APOBEC1 recombinant antibodies. Our full portfolio of rAbs is carefully validated and made with the consistency and rigor you need to study this important enzyme. Let us help you build a solid foundation for your research. Please reach out to our scientific team today.