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APOBEC1
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (CAPAN-2, OE19)
Interaction
Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP.
Molecular function
Hydrolase
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