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APOBEC1

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Proximal enterocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (CAPAN-2, OE19)

Interaction

Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP.

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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