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APOE
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Muller glia cells, Hepatocytes, Proximal tubular cells, Theca cells, Hofbauer cells, Peritubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC diff, CACO-2, Hep G2, HSkMC, SK-MEL-30)
Interaction
Homotetramer (PubMed:8340399). May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs (PubMed:14754908). May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear (PubMed:8367470, PubMed:23620513). May interact with MAPT (PubMed:7972031). May interact with MAP2 (PubMed:7891887). In the cerebrospinal fluid, interacts with secreted SORL1 (PubMed:30448281). (Microbial infection) Interacts with hepatitis C virus (HCV) envelope glycoprotein E2; this interaction is required for HCV infectivity and production.
Molecular function
Heparin-binding
More Types Infomation
- Rabbit Anti-APOE Polyclonal Antibody (MRO-1656-CN) (MRO-1656-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Rabbit Anti-APOE Recombinant Antibody (clone CBACN-038) (MRO-0113-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
- Mouse Anti-APOE Recombinant Antibody (clone F7E8) (MOB-0669MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IHC-Fr, IHC-P, IP, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, ICC, IF, IHC, IP
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, ICC
- Recombinant Mouse Anti-APOE Antibody (NEUT-024CQ)
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- Type: IgG
- Application: ELISA, BL
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, IHC-P, IP, WB
- Mouse Anti-APOE Recombinant Antibody (clone 2E8); scFv Fragment (HPAB-0115CQ-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, Block
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
- Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0315-YC-S(P)) (HPAB-N0315-YC-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
- Mouse Anti-APOE Recombinant Antibody (HPAB-N0316-YC) (HPAB-N0316-YC)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
- Mouse Anti-APOE Recombinant Antibody (clone 2E8); Fab Fragment (HPAB-0115CQ-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, Block
- Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0315-YC-F(E)) (HPAB-N0315-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
- Mouse Anti-APOE Recombinant Antibody (HPAB-N0315-YC) (HPAB-N0315-YC)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
-
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, IHC, FC, FuncS
- Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0318-YC-S(P)) (HPAB-N0318-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
- Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0318-YC-F(E)) (HPAB-N0318-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: DB, ELISA, WB, IP
- Mouse Anti-APOE Recombinant Antibody (HPAB-N0318-YC) (HPAB-N0318-YC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
- Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0317-YC-S(P)) (HPAB-N0317-YC-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: IP, ELISA, WB
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For Research Use Only. Not For Clinical Use.