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APOL1

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
Protein class

Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Glandular and luminal cells, Hepatocytes, Endometrial ciliated cells, Pancreatic endocrine cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (EFO-21, HDLM-2, HHSteC, RPTEC TERT1, RT4)

Interaction

In plasma, interacts with APOA1 and mainly associated with large high density lipoprotein particles.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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