ASF1

ASF1 like histone chaperone family of proteins includes the yeast and human ASF1 proteins. These proteins are of the chaperone protein group and in particular can be placed into the histone chaperone subgroup. ASF1 participates in both the replication-dependent and replication-independent pathways. The three-dimensional structure has been determined as a compact immunoglobulin-like beta sandwich fold topped by three helical linkers.Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. It cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and plays a role in the formation of silent heterochromatin.