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ATG10

Anti-ATG10 Products

Rabbit Anti-ATG10 Recombinant Antibody (clone R02-0B2) (VS3-FY1973)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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Mouse Anti-ATG10 Recombinant Antibody (clone 3F3C2) (VS7-HM148)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
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Mouse Anti-ATG10 Recombinant Antibody (clone 8A9B3) (VS7-HM149)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FCM
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Hi-Affi™ Rabbit Anti-ATG10 Recombinant Antibody (clone DS277AB) (MOR-0277)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.

Background

Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form.

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). Interacts with IRGM.

Molecular function

Transferase

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