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ATP2A3
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Gastric mucus-secreting cells, Intestinal goblet cells, Distal enterocytes, Enteroendocrine cells, Plasma cells, B-cells, Undifferentiated cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HMC-1, JURKAT, MOLT-4, SK-BR-3)
Interaction
Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). Interacts VMP1 (PubMed:28890335). Interacts with TUNAR; the interaction occurs at low levels in low glucose conditions and is increased by high glucose levels (PubMed:34513312).
Molecular function
Translocase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
Related Diseases
Morphine Addiction
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, IHC, WB
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ICC, IHC-P, WB
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For Research Use Only. Not For Clinical Use.