Anti-ACAT1 Recombinant Antibody Products

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Anti-ACAT1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs delivers high-performance recombinant antibodies against ACAT1 to support the advancement of biomedical research. Through the use of cutting-edge technologies and refined production systems, we ensure our products consistently meet rigorous standards for quality and reliability. Our comprehensive selection of recombinant antibodies is crafted to provide dependable tools that add value to a wide range of scientific applications. In addition to offering top-tier reagents, we are committed to providing responsive technical assistance to guide researchers through every phase of their work. Partnering with Creative Biolabs means accessing both innovative antibody solutions and a reliable resource dedicated to your research success.

ACAT1: A Central Mediator in Metabolic Neurological and Cardiovascular Disorders

ACAT1 has been increasingly recognized for its involvement in various disease pathways, particularly those related to lipid metabolism and mitochondrial function. This mitochondrial enzyme plays a crucial role in ketone body metabolism and cholesterol esterification, processes essential for energy homeostasis and membrane integrity. Abnormal activity has been linked to metabolic disorders such as mitochondrial acetoacetyl-CoA thiolase deficiency, a rare condition characterized by episodic ketoacidosis and developmental delays. Beyond inherited metabolic syndromes, altered expression has also been observed in several cancers, where it may contribute to tumor progression by supporting lipid storage and modifying cellular energy dynamics. In neurodegenerative diseases like Alzheimer's, dysregulation appears to impact cholesterol turnover and mitochondrial stability, potentially exacerbating oxidative stress and neuronal damage. Its function in macrophage lipid handling also implicates it in atherosclerosis, as foam cell formation and plaque development are influenced by intracellular cholesterol processing. As research continues, its role in integrating metabolic and inflammatory signals places it at the intersection of several critical disease mechanisms, making it a promising focus for therapeutic strategies.

Alternative Names

Complement Acetyl-CoA Acetyltransferase 1; Acetyl-Coenzyme A Acetyltransferase 1; Acetoacetyl Coenzyme A Thiolase; Acetoacetyl-CoA Thiolase; EC 2.3.1.9; ACAT; MAT

Background

This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

Anti-ACAT1 rAb Products

Our anti-ACAT1 recombinant antibodies are engineered to support your research with rigorously validated performance and batch-to-batch consistency. Alongside these reliable tools, we offer personalized technical guidance to help optimize protocols for applications like WB, IHC, or flow cytometry. Whether you're screening targets or validating findings, we aim to provide practical solutions that save time while maintaining high standards.

Creative Quality Control

To accelerate biopharmaceutical research and development from discovery to commercialization, our core values are anchored in a customer-centric philosophy, with primary emphasis on addressing customer needs for product excellence. We have established a rigorous quality management system to ensure consistent product quality, striving to exceed customer expectations and assist in accelerating drug development timelines.

Customer Reviews

Excellent

M**hi
Recombinant Rabbit Anti-ACAT1 Antibody (clone R02-5G8) (CAT#: VS3-FY13)

We used the Recombinant Rabbit Anti-ACAT1 Antibody for Western blotting on human liver cell lysates. The antibody produced clear, specific bands with minimal background, and worked well with our standard detection system. It didn’t require much optimization, which saved time in our workflow. Overall, a reliable choice for protein detection in metabolic studies.

18/Oct/2024

Excellent

St**g
Rabbit Anti-ACAT1 Recombinant Antibody (clone DS31AB) (CAT#: MOR-0031)

Used the Anti-ACAT1 for IP in HepG2 lysates. Pulled down clean ACAT1 at ~50kDa with minimal nonspecific binding when used at 1:50 dilution. Compared well to our usual antibody, though we needed to optimize wash conditions (added 300mM NaCl) to reduce background. Worked less efficiently in mouse liver homogenates - might need more antibody for tissue samples. Solid performance for cell-based IP applications.

06/Jul/2023

rAb Production

Backed by years of specialized experience in recombinant antibody engineering, we provide rigorously validated antibodies that meet stringent quality requirements. Our optimized development process combines technical accuracy with efficient timelines, delivering reliable research tools without compromising performance standards.

Featured Anti-ACAT1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-ACAT1 recombinant antibody production.

Fig.3 Gram-scale anti-ACAT1 recombinant antibody production.

rAb Modalities

Creative Biolabs specializes in developing high-performance recombinant antibodies for diverse research applications. Leveraging advanced engineering techniques, we offer customizable solutions tailored to specific experimental needs. Our antibodies undergo rigorous validation to ensure reliable results across various formats and applications.

Fig.4 Full Length Anti-ACAT1 Recombinant Antibody Production and Modalities

For any further detailed information on target ACAT1, please do not hesitate to contact us by phone or email at your convenience. Our expert team is readily available to help you tackle any queries or experimental challenges that may arise during your work, ensuring you receive all necessary support for research success.