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ADAM9

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Pancreatic endocrine cells)

Immune cell specificity

Immune cell enhanced (classical monocyte)

Cell line specificity

Low cell line specificity

Interaction

Interacts with SH3GL2 and SNX9 through its cytoplasmic tail (PubMed:10531379). Interacts with ITGA6.

Molecular function

Hydrolase, Metalloprotease, Protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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