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AGBL1
Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy.
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Astrocytes, Inhibitory neurons, Alveolar cells type 2, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Interacts with MYLK (By similarity). Interacts with TCF4 (PubMed:24094747).
Molecular function
Carboxypeptidase, Hydrolase, Metalloprotease, Protease
More Types Infomation
- Recombinant Anti-Human AGBL1 Antibody (MOB-2960z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC, FuncS
- Recombinant Anti-Human AGBL1 Antibody scFv Fragment (MOB-2960z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FC, FuncS
- Recombinant Anti-Human AGBL1 Antibody Fab Fragment (MOB-2960z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, Nert, FuncS
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For Research Use Only. Not For Clinical Use.