Alkaline Phosphatase

Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) (EC 3.1.3.1) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation. As the name suggests, alkaline phosphatases are most effective in an alkaline environment. It is sometimes used synonymously as basic phosphatase.

Alkaline Phosphatase, orally administered, shows a favorable safety profile by locally countering colon inflammation in ulcerative colitis patients.

phoA, or Alkaline phosphatase, is an enzyme that non-specifically hydrolyzes phosphate monoesters at alkaline pH, releasing inorganic phosphate. PhoA is typically periplasmic in Gram-negative bacteria and is highly expressed under phosphate-limiting conditions, playing a crucial role in acquiring phosphate from organic sources. It is widely used as a reporter enzyme in molecular biology.

Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. In humans, alkaline phosphatase is present in all tissues throughout the entire body, but is particularly concentrated in liver, bile duct, kidney, bone, intestinal mucosa and the placenta. It is widely used in diagnostics.