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ANTXR1

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Astrocytes, Skeletal myocytes, Endometrial stromal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (LHCN-M2, TIME)

Interaction

Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. (Microbial infection) Interacts (via VWFA domain) with the protective antigen (PA) of B.anthracis (PubMed:11700562, PubMed:12700348, PubMed:16762926, PubMed:20585457). Binding does not occur in the presence of calcium (PubMed:11700562, PubMed:12700348, PubMed:16762926, PubMed:20585457).

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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